4.7 Review

Iron homeostasis in arthropathies: From pathogenesis to therapeutic potential

Related references

Note: Only part of the references are listed.
Article Cell Biology

Involvement of oxidative stress-induced annulus fibrosus cell and nucleus pulposus cell ferroptosis in intervertebral disc degeneration pathogenesis

Run-Ze Yang et al.

Summary: The study demonstrates the involvement of ferroptosis in the pathogenesis of intervertebral disc degeneration (IVDD) by detecting changes in protein levels and lipid peroxidation during oxidative stress. Treatment with ferroptosis inhibitors and ferritinophagy supports the role of ferroptosis in IVDD.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

Review Biochemistry & Molecular Biology

Musculoskeletal complications associated with pathological iron toxicity and its molecular mechanisms

Marcio Simao et al.

Summary: Iron levels in the body must be controlled through iron-chelating molecules and phlebotomy to prevent toxic events that can affect bone and cartilage health. Understanding the molecular mechanisms of iron toxicity and tissue microenvironment is crucial in preventing the progression of complications.

BIOCHEMICAL SOCIETY TRANSACTIONS (2021)

Article Cell Biology

The detrimental effect of iron on OA chondrocytes: Importance of pro-inflammatory cytokines induced iron influx and oxidative stress

Xingzhi Jing et al.

Summary: In this study, it was found that pro-inflammatory cytokines disrupt iron homeostasis in chondrocytes, leading to iron overload and upregulation of catabolic markers. Oxidative stress and mitochondrial dysfunction play crucial roles in iron overload-induced cartilage degeneration.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Article Cardiac & Cardiovascular Systems

Atherosclerosis is aggravated by iron overload and ameliorated by dietary and pharmacological iron restriction

Francesca Vinchi et al.

EUROPEAN HEART JOURNAL (2020)

Article Orthopedics

Systemic iron overload exacerbates osteoarthritis in the strain 13 guinea pig

L. H. Burton et al.

OSTEOARTHRITIS AND CARTILAGE (2020)

Review Medicine, General & Internal

Osteoarthritis

David J. Hunter et al.

LANCET (2019)

Review Pharmacology & Pharmacy

Iron chelators in obesity therapy - Old drugs from a new perspective?

Thaind Rodrigues de Morais et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

Review Biochemistry & Molecular Biology

Programmed Cell-Death by Ferroptosis: Antioxidants as Mitigators

Naroa Kajarabille et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biochemistry & Molecular Biology

Hepcidin protects against iron overload-induced inhibition of bone formation in zebrafish

Yu Jiang et al.

FISH PHYSIOLOGY AND BIOCHEMISTRY (2019)

Review Biochemistry & Molecular Biology

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

Matthew Dodson et al.

REDOX BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Expression of iron-regulators in the bone tissue of rats with and without iron overload

Yanqin Li et al.

BIOMETALS (2018)

Article Hematology

Joint disease in haemophilia: Pathophysiology, pain and imaging

L. F. D. van Vulpen et al.

HAEMOPHILIA (2018)

Article Cell Biology

Iron overload induces G1 phase arrest and autophagy in murine preosteoblast cells

Wan-Jing Cen et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

Article Endocrinology & Metabolism

Iron-induced oxidative stress stimulates osteoclast differentiation via NF-κB signaling pathway in mouse model

Xiao Wang et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2018)

Article Cell Biology

Targeting mitochondrial responses to intra-articular fracture to prevent posttraumatic osteoarthritis

Mitchell C. Coleman et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

Review Cell Biology

An overview of the role of lipid peroxidation-derived 4-hydroxynonenal in osteoarthritis

Jamilah Abusarah et al.

INFLAMMATION RESEARCH (2017)

Article Medicine, General & Internal

Regulation of DMT1 on autophagy and apoptosis in osteoblast

Fei Liu et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2017)

Review Biochemistry & Molecular Biology

Cytosolic iron chaperones: Proteins delivering iron cofactors in the cytosol of mammalian cells

Caroline C. Philpott et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Review Pharmacology & Pharmacy

Pathophysiology of hemophilic arthropathy and potential targets for therapy

Astrid E. Pulles et al.

PHARMACOLOGICAL RESEARCH (2017)

Review Pharmacology & Pharmacy

Clinical Impact and Cellular Mechanisms of Iron Overload-Associated Bone Loss

Viktoria Jeney

FRONTIERS IN PHARMACOLOGY (2017)

Article Nutrition & Dietetics

Current understanding of iron homeostasis

Gregory J. Anderson et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2017)

Review Biochemistry & Molecular Biology

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Brent R. Stockwell et al.

Article Cell Biology

Autophagy promotes ferroptosis by degradation of ferritin

Wen Hou et al.

AUTOPHAGY (2016)

Article Biochemistry & Molecular Biology

Dominant roles of Fenton reaction in sodium nitroprusside-induced chondrocyte apoptosis

Ying-Yao Quan et al.

FREE RADICAL BIOLOGY AND MEDICINE (2016)

Review Orthopedics

Mesenchymal stromal cells for cartilage repair in osteoarthritis

M. K. Mamidi et al.

OSTEOARTHRITIS AND CARTILAGE (2016)

Review Biochemistry & Molecular Biology

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease

Alexander R. Bogdan et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

Review Pathology

The detrimental effects of iron on the joint: a comparison between haemochromatosis and haemophilia

Lize F. D. van Vulpen et al.

JOURNAL OF CLINICAL PATHOLOGY (2015)

Article Biochemistry & Molecular Biology

Effects of dietary resveratrol on excess-iron-induced bone loss via antioxidative character

Lu Zhao et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2015)

Article Biochemistry & Molecular Biology

Glutaminolysis and Transferrin Regulate Ferroptosis

Minghui Gao et al.

MOLECULAR CELL (2015)

Article Biochemistry & Molecular Biology

HSPB1 as a novel regulator of ferroptotic cancer cell death

X. Sun et al.

ONCOGENE (2015)

Review Rheumatology

Emerging regulators of the inflammatory process in osteoarthritis

Ru Liu-Bryan et al.

NATURE REVIEWS RHEUMATOLOGY (2015)

Article Biochemistry & Molecular Biology

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

David Devos et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

Review Developmental Biology

Chondrocyte hypertrophy in skeletal development, growth, and disease

Margaret Man-Ger Sun et al.

BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS (2014)

Article Biochemistry & Molecular Biology

Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang et al.

Review Clinical Neurology

The role of iron in brain ageing and neurodegenerative disorders

Roberta Ward et al.

LANCET NEUROLOGY (2014)

Article Multidisciplinary Sciences

Hemolysis-induced lethality involves inflammasome activation by heme

Fabianno F. Dutra et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Hematology

Deferasirox limits cartilage damage following haemarthrosis in haemophilic mice

Laurens Nieuwenhuizen et al.

THROMBOSIS AND HAEMOSTASIS (2014)

Review Biochemistry & Molecular Biology

Lysosomal Iron, Iron Chelation, and Cell Death

Alexei Terman et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Review Oncology

Iron and cancer: more ore to be mined

Suzy V. Torti et al.

NATURE REVIEWS CANCER (2013)

Review Biochemistry & Molecular Biology

Hepcidin and iron homeostasis

Tomas Ganz et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2012)

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

Article Gastroenterology & Hepatology

Iron sensing and signalling

Rayko Evstatiev et al.

Review Rheumatology

Bone remodelling in osteoarthritis

David B. Burr et al.

NATURE REVIEWS RHEUMATOLOGY (2012)

Review Rheumatology

Metabolic syndrome meets osteoarthritis

Qi Zhuo et al.

NATURE REVIEWS RHEUMATOLOGY (2012)

Article Endocrinology & Metabolism

Iron excess limits HHIPL-2 gene expression and decreases osteoblastic activity in human MG-63 cells

M. Doyard et al.

OSTEOPOROSIS INTERNATIONAL (2012)

Article Hematology

Neoangiogenesis contributes to the development of hemophilic synovitis

Suchitra S. l Acharya et al.

BLOOD (2011)

Article Endocrinology & Metabolism

Bone status in a mouse model of genetic hemochromatosis

P. Guggenbuhl et al.

OSTEOPOROSIS INTERNATIONAL (2011)

Article Rheumatology

Synovial immunopathology in haemochromatosis arthropathy

Gisela Ruiz Heiland et al.

ANNALS OF THE RHEUMATIC DISEASES (2010)

Article Biochemistry & Molecular Biology

Iron-mediated oxidative stress plays an essential role in ferritin-induced cell death

Nikolaus Bresgen et al.

FREE RADICAL BIOLOGY AND MEDICINE (2010)

Article Endocrinology & Metabolism

Ferritin Ferroxidase Activity: A Potent Inhibitor of Osteogenesis

Abolfazl Zarjou et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2010)

Article Biochemistry & Molecular Biology

Coordination of PGC-1 beta and iron uptake in mitochondrial biogenesis and osteoclast activation

Kiyo-aki Ishii et al.

NATURE MEDICINE (2009)

Article Sport Sciences

The Basic Science of Articular Cartilage: Structure, Composition, and Function

Alice J. Sophia Fox et al.

SPORTS HEALTH-A MULTIDISCIPLINARY APPROACH (2009)

Article Pharmacology & Pharmacy

Regulation of inflammation signalling by resveratrol in human chondrocytes in vitro

Constanze Csaki et al.

BIOCHEMICAL PHARMACOLOGY (2008)

Review Biochemistry & Molecular Biology

The role of iron regulatory proteins in mammalian iron homeostasis and disease

Tracey A. Rouault

NATURE CHEMICAL BIOLOGY (2006)

Article Cell Biology

The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis

A Donovan et al.

CELL METABOLISM (2005)

Article Biochemistry & Molecular Biology

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

RJ Appelhoff et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Pathology

Short-term exposure of cartilage to blood results in chondrocyte apoptosis

M Hooiveld et al.

AMERICAN JOURNAL OF PATHOLOGY (2003)

Review Biochemistry & Molecular Biology

The labile iron pool: Characterization, measurement, and participation in cellular processes

O Kakhlon et al.

FREE RADICAL BIOLOGY AND MEDICINE (2002)