Journal
ADVANCES IN THERAPY
Volume 38, Issue 11, Pages 5534-5547Publisher
SPRINGER
DOI: 10.1007/s12325-021-01910-8
Keywords
Contact lens; Contrast sensitivity; Diquafosol; Dry eye; Tear film; Visual function
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The study showed that diquafosol ophthalmic solution is effective and safe for soft contact lens-related dry eye, improving symptoms and contrast sensitivity without adverse events.
Introduction This study evaluated the efficacy and safety of diquafosol ophthalmic solution (DQS) in soft contact lens (SCL)-related dry eye using artificial tear as a control. Methods This study enrolled 26 patients with SCL-related dry eye. DQS and artificial tears (AT) were instilled into the right and left eyes, respectively, with their SCLs on. Dry eye examinations (including tear film breakup time, tear volume, and staining score) were performed and visual function (including contrast sensitivity) was also evaluated before (at baseline) and after treatment (at 4- and 8-week examinations). Subjective symptoms were assessed separately in each eye using a questionnaire on dry eye in contact lens wearers. The results were compared before and after treatment, and between the right eyes treated with DQS (the DQS eye) and the left eyes treated with AT (the AT eye) using the mixed effect model. Results Corneal and conjunctival staining scores at 8-week examination were significantly lower than those at baseline in the DQS eye (p = 0.03; p < 0.001, respectively), but no significant changes were observed in the AT eye. Most subjective symptoms improved significantly in both the DQS and AT eyes. However, major subjective symptoms (dryness and blurry vision) improved significantly only in the DQS eye at 8-week examination. Contrast sensitivity at 8-week examination in the DQS eye improved significantly at 12 cycles/degree compared to baseline (p = 0.001) and was significantly better than that in the AT eye (p = 0.03). There were no adverse events related to DQS or AT. Conclusions DQS was effective and safe for SCL-related dry eye. DQS also improved contrast sensitivity.
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