Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 364, Issue 7, Pages 1264-1270Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202101489
Keywords
Rhodium; alkyne; 2-pyridone; annulation; alkenylation; C-H activation
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Funding
- National Natural Science Foundation of China [21372258, 21671151, 21673289]
- Renmin University of China
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Cp*Rh(III)-catalyzed regioselective C-H annulation and alkenylation of 2-pyridones with terminal alkynes has been developed, providing efficient access to diversified compounds.
Cp*Rh(III)-catalyzed regioselective C-H annulation and alkenylation of 2-pyridones with terminal alkynes have been developed. The cationic Cp*Rh(III) catalytic system containing FeCl3 additive enables annulation of 1-(2-pyridyl)-2-pyridones with terminal alkynes, providing efficient access to 5,7-diarylated 2-quinolinones. The reaction pathway can be switched to alkenylation with [Cp*RhCl2](2) as the catalyst, NaOAc as the additive and HOAc as the solvent, affording C6-alkenylated 1-(2-pyridyl)-2-pyridones in high yields. These protocols accommodate a wide range of substrates with good functional group compatibility.
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