Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 364, Issue 4, Pages 890-896Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202101232
Keywords
tandem cyclization; bismuth catalysis; tryptamine-derived ynamide; pentacyclic spiroindoline; tricyclic indole derivative
Categories
Funding
- Natural Science Foundation of China [22171056]
- Featured Innovation Project of Guangdong University [2020KTSCX094]
- Guangdong Natural Science Foundation [2021A1515010072]
- Guangzhou Municipal Science and Technology Project [202102020784]
- Open Fund of Guangdong Provincial Key Laboratory of Catalysis [2020B121201002]
- University (Institute) Joint Funding (High-level University) Basic Research Project [202102010397, 202102010468]
- project of State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medicial University [QJHKY[2022]389]
Ask authors/readers for more resources
This study presented a BiCl3-mediated tandem cyclization reaction of tryptamine-ynamides, leading to the formation of pentacyclic spiroindoline scaffolds in moderate to excellent yields. The reaction also demonstrated the divergent synthesis of tricyclic indole derivatives with moderate yields by manipulating substrate structures, showcasing the synthetic utility of the methodology.
Catalytic tandem cyclization of ynamides has attracted considerable interest in organic synthesis because of its atom economy in the rapid formation of polycyclic compounds. However, examples on the construction of pentacyclic spiroindolines are quite scarce. Herein, we described a BiCl3-mediated tandem cyclization reaction of tryptamine-ynamides, which led to the formation of appealing pentacyclic spiroindoline scaffolds in moderate to excellent yields. In addition, such a reaction can lead to the divergent synthesis of tricyclic indole derivatives with moderate yields by engineering substrate structures. The synthetic utility of this methodology has also been demonstrated by further interesting transformations.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available