A Synthetic Protocol for the Construction of Chroman-Spiroquinazolin(thi)one Framework via a Metal-Free, Three-Component, Domino, Double Annulations

A three-component domino approach for the synthesis of chroman-spiroquinazolin(thi)ones is described. It involves a condensation of 2-aminoacetophenones and iso(thio)cyanates followed by a hetero-Diels-Alder annulation with 2-hydroxybenzyl alcohol derivatives. The reaction exhibits a broad substrate scope under a metal-free catalytic condition.

Automated summary

A three-component domino approach for the synthesis of chroman-spiroquinazolin(thi)ones is described, which involves a condensation reaction followed by a hetero-Diels-Alder annulation. The reaction shows broad substrate scope and can be conducted under metal-free catalytic conditions.