Iodine-Catalyzed Double [4+2] Oxidative Annulations for the Synthesis of Bipyrazines from Ketones and Diamines by a Domino Strategy

An iodine-catalyzed double [4+2] oxidative annulation of ketones and diamines is described. A multi-pathway coupled domino strategy has been developed for the synthesis of substituted dimeric pyrazines under metal-free conditions. One C-C and four C-N bonds are formed during this double [4+2] oxidative annulation process from two ketones and two diamines.

Automated summary

An iodine-catalyzed double [4+2] oxidative annulation of ketones and diamines is reported, leading to the synthesis of substituted dimeric pyrazines under metal-free conditions through a multi-pathway coupled domino strategy. During this process, one C-C and four C-N bonds are formed from two ketones and two diamines.