Journal
ADVANCED MATERIALS
Volume 33, Issue 49, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202102950
Keywords
bio-orthogonal labeling; lanthanide-doped nanoparticles; MRI; NIR-IIb fluorescence; tumor imaging
Categories
Funding
- National Key & Program of China [2018YFA0902600, 2017YFE0120000]
- National Natural Science Foundation of China [21635002, 21771135, 21871071, 91859117, 81771906, 81901812]
- Ministry of Education, Singapore [MOE2017-T2-2-110]
- Agency for Science, Technology and Research (A*STAR) [A1883c0011, A1983c0038]
- National Research Foundation
- Prime Minister's Office of Singapore [NRF-NRFI05-2019-0003]
- Science and Technology Key Project of Shenzhen [JCYJ20190812163614809, JCYJ20200109114612308]
- Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province [2020B1212060051]
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This study introduces the use of bioorthogonal nanoprobes with high tumor-targeting specificity for in vivo NIR-IIb luminescence imaging and MRI, improving imaging quality and reducing toxicity.
Lanthanide-based NIR-IIb nanoprobes are ideal for in vivo imaging. However, existing NIR-IIb nanoprobes often suffer from low tumor-targeting specificity, limiting their widespread use. Here the application of bioorthogonal nanoprobes with high tumor-targeting specificity for in vivo NIR-IIb luminescence imaging and magnetic resonance imaging (MRI) is reported. These dual-modality nanoprobes can enhance NIR-IIb emission by 20-fold and MRI signal by twofold, compared with non-bioorthogonal nanoprobes in murine subcutaneous tumors. Moreover, these bioorthogonal probes enable orthotopic brain tumor imaging. Implementation of bio-orthogonal chemistry significantly reduces the nanoprobe dose and hence cytotoxicity, providing a paradigm for real-time in vivo visualization of tumors.
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