Journal
ADVANCED MATERIALS
Volume 33, Issue 49, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202104829
Keywords
biomaterials; bone regeneration; micro; nanostructures; microbial catalysis
Categories
Funding
- National Key Research and Development Program of China [2018YFB1105501]
- Natural Science Foundation of China [81901899]
- Innovation Cross Team of Chinese Academy Sciences [JCTD-2018-13]
- Shanghai Sailing Program [19YF1454100]
- Science and Technology Commission of Shanghai Municipality [20442420300]
- China Postdoctoral Science Foundation [2018M642095]
- Youth Innovation Promotion Association CAS [2021249]
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By utilizing microbial catalysis, uniform micro/nanostructures can be biologically synthesized on the surface of bioceramics, which exhibit excellent in vitro and in vivo bone-forming bioactivity. This bioinspired approach involves bacterial adhesion on biomaterials, bacterial-assisted production of CO32-, and nucleation and growth of CaCO3 nanocrystals on the surface of bioceramics.
Bone is a complex mineralized tissue composed of various organic (proteins, cells) and inorganic (hydroxyapatite, calcium carbonate) substances with micro/nanoscale structures. To improve interfacial bioactivity of bone-implanted biomaterials, extensive efforts are being made to fabricate favorable biointerface via surface modification. Inspired by microbially catalyzed mineralization, a novel concept to biologically synthesize the micro/nanostructures on bioceramics, microbial-assisted catalysis, is presented. It involves three processes: bacterial adhesion on biomaterials, production of CO32- assisted by bacteria, and nucleation and growth of CaCO3 nanocrystals on the surface of bioceramics. The microbially catalyzed biominerals exhibit relatively uniform micro/nanostructures on the surface of both 2D and 3D alpha-CaSiO3 bioceramics. The topographic and chemical cues of the grown micro/nanostructures present excellent in vitro and in vivo bone-forming bioactivity. The underlying mechanism is closely related to the activation of multiple biological processes associated with bone regeneration. The study offers a microbially catalytic concept and strategy of fabricating micro/nanostructured biomaterials for tissue regeneration.
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