4.8 Review

Bioactive Synthetic Polymers

Journal

ADVANCED MATERIALS
Volume 34, Issue 2, Pages -

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202105063

Keywords

anticancer polymers; antimicrobial polymers; antiviral polymers; bioactive synthetic polymers; molecular recognition

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Synthetic polymers are widely used in society for various applications, while natural polymers are essential for life and environmental adaptation. Recent advancements in synthetic polymerization techniques have led to the development of bioactive synthetic polymers with specific biological functions, opening up new opportunities for biomedical applications.
Synthetic polymers are omnipresent in society as textiles and packaging materials, in construction and medicine, among many other important applications. Alternatively, natural polymers play a crucial role in sustaining life and allowing organisms to adapt to their environments by performing key biological functions such as molecular recognition and transmission of genetic information. In general, the synthetic and natural polymer worlds are completely separated due to the inability for synthetic polymers to perform specific biological functions; in some cases, synthetic polymers cause uncontrolled and unwanted biological responses. However, owing to the advancement of synthetic polymerization techniques in recent years, new synthetic polymers have emerged that provide specific biological functions such as targeted molecular recognition of peptides, or present antiviral, anticancer, and antimicrobial activities. In this review, the emergence of this generation of bioactive synthetic polymers and their bioapplications are summarized. Finally, the future opportunities in this area are discussed.

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