Journal
ADVANCED MATERIALS
Volume 33, Issue 48, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202106768
Keywords
3D printing scaffold; cancer immunotherapy; cancer vaccine; combination therapy
Categories
Funding
- National Natural Science Foundation of China [31900988]
- Natural Science Foundation of Jiangsu Province [SBK2019040088]
- Jiangsu Province Six Talent Peaks Project [SWYY-110]
- Collaborative Innovation Center of Suzhou Nano Science and Technology
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- 111 Project
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A 3D printed scaffold loaded with immunoregulators has been developed for enhanced cancer immunotherapy, showing potential as a strategy for cancer vaccine therapy in the future.
Cancer vaccine platform has attracted great interest in the field of cancer immunotherapy. Here, 3D printed scaffolds loaded with immunoregulators are developed for enhanced cancer immunotherapy. The rapid manufacturing and precise molding based on 3D printing can realize the mass manufacturing of cancer vaccines and personalized design. Meanwhile, compared to the traditional hydrogel, the 3D-scaffold with porous structure endows its similar functions compared with real lymphoid organs by recruitment of a great number of immune cells, leading to the formation of artificial tertiary lymphoid structures, where there is a promising site to enhance both humoral and cellular immune responses. Efficient anticancer immunity is induced when combined with immune checkpoint blockade to inhibit the tumor growth. Personalized antitumor scaffold vaccines are further demonstrated for filling of tumor site after surgery to prevent cancer metastasis. Taken together, these results promise the 3D printing scaffold vaccine as the potential strategy for cancer vaccine therapy in the future.
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