Journal
ADVANCED MATERIALS
Volume 34, Issue 9, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202106994
Keywords
aggregation-induced emission; atherosclerosis; CD47 antibody; early detection; fluorescence imaging
Categories
Funding
- National Natural Science Foundation of China (NSFC) [81921004, 51961160730, 51873092, 81772000, 91939112, 21806082]
- NSFC Research Fund for International Young Scientists [81850410552]
- National Key R&D Program of China [2017YFE0132200, 2019YFA0210100]
- Tianjin Natural Science Foundation [20JCYBJC01150]
- Tianjin Science Fund for Distinguished Young Scholars [19JCJQJC61200]
- Tianjin Project + Team Key Training Foundation [XC202035]
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This article introduces a highly bright aggregation-induced emission (AIE) nanoprobe for the precise detection of atherosclerotic plaque at an early stage and the screening of anti-atherosclerosis drugs. The nanoprobes show high molar extinction coefficient, large photoluminescence quantum yield, and redshifted absorption/emission spectra compared to control compounds. These nanoprobes efficiently recognize atherosclerotic plaque at different stages and can be used to monitor the therapeutic effects of anti-atherosclerosis drugs.
Fluorescent probes capable of precise detection of atherosclerosis (AS) at an early stage and fast assessment of anti-AS drugs in animal level are particularly valuable. Herein, a highly bright aggregation-induced emission (AIE) nanoprobe is introduced by regulating the substituent of rhodanine for early detection of atherosclerotic plaque and screening of anti-AS drugs in a precise, sensitive, and rapid manner. With dicyanomethylene-substituted rhodanine as the electron-withdrawing unit, the AIE luminogen named TPE-T-RCN shows the highest molar extinction coefficient, the largest photoluminescence quantum yield, and the most redshifted absorption/emission spectra simultaneously as compared to the control compounds. The nanoprobes are obtained with an amphiphilic copolymer as the matrix encapsulating TPE-T-RCN molecules, which are further surface functionalized with anti-CD47 antibody for specifically binding to CD47 overexpressed in AS plaques. Such nanoprobes allow efficient recognition of AS plaques at different stages in apolipoprotein E-deficient (apoE(-/-)) mice, especially for the recognition of early-stage AS plaques prior to micro-computed tomography (CT) and magnetic resonance imaging (MRI). These features impel to apply the nanoprobes in monitoring the therapeutic effects of anti-AS drugs, providing a powerful tool for anti-AS drug screening. Their potential use in targeted imaging of human carotid plaque is further demonstrated.
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