Journal
ADVANCED MATERIALS
Volume 33, Issue 52, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202106996
Keywords
chemodynamic therapy; nanocatalytic therapy; nanozymes; photodynamic therapy; photothermal therapy
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Funding
- NNSF of China [62120106002, 61935004, 51803091]
- Jiangsu Province Policy Guidance Plan [BZ2019014]
- Natural Science Foundation of Shandong Province [ZR2020KB018]
- Taishan scholars construction special fund of Shandong Province
- Ministry of Education of Singapore [MOE2019-T2-2-004]
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A novel all-in-one Fe3O4/Ag/Bi2MoO6 nanoparticle (FAB NP) is designed for synergistic chemodynamic, photodynamic, and photothermal therapy in the tumor microenvironment, demonstrating outstanding therapeutic outcomes. The mechanisms of intraparticulate interactions, sustainability, and self-replenishment are carefully revealed, providing new insights into the design of novel nanozymes for efficient nanocatalytic therapy with high specificity and low side effects.
Catalytic cancer therapy based on nanozymes has recently attracted much interest. However, the types of the current nanozymes are limited and their efficiency is usually compromised and not sustainable in the tumor microenvironment (TME). Therefore, combination therapy involving additional therapeutics is often necessary and the resulting complication may jeopardize the practical feasibility. Herein, an unprecedented all-in-one Fe3O4/Ag/Bi2MoO6 nanoparticle (FAB NP) is rationally devised to achieve synergistic chemodynamic, photodynamic, photothermal therapy with guidance by magnetic resonance, photoacoustic, and photothermal imaging. Based on its manifold nanozyme activities (mimicking peroxidase, catalase, superoxide dismutase, glutathione oxidase) and photodynamic property, cascaded nanocatalytic reactions are enabled and sustained in TME for outstanding therapeutic outcomes. The working mechanisms underlying the intraparticulate interactions, sustainability, and self-replenishment arising from the coupling between the nanocatalytic reactions and nanozyme activities are carefully revealed, providing new insights into the design of novel nanozymes for nanocatalytic therapy with high efficiency, good specificity, and low side effects.
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