Journal
ADVANCED MATERIALS
Volume 33, Issue 45, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202007949
Keywords
bioengineered organoids; biomaterials; disease modeling; extracellular matrix; genetic engineering
Categories
Funding
- NIH [R21AR071101, 1R01DC016612-01, 3R01DC016612-01S1, R01DC016612-02S1, R01DC016612-04S1]
- New Jersey Commission on Spinal Cord Research [CSCR17IRG010, CSCR16ERG019]
- NSF [CBET-1803517]
- New Jersey Health Foundation [PC16-21CV]
- Brain Health Institute (BHI) at Rutgers University
- Rutgers TechAdvance program
- Rutgers Grossman Innovation Prize
- Busch Biomedical Grant
- Burroughs Wellcome Fund
- National Research Foundation of Korea [2017R1A6A3A04001986]
- National Research Foundation of Korea [2017R1A6A3A04001986] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Recent advances in 3D cell culture technology have enabled scientists to generate stem cell derived organoids that mimic the structural and functional characteristics of native organs. Current technologies are striving to identify essential factors for controlling organoid development processes, while there is a growing demand for engineering dynamic environments to generate reproducible and reliable organoids. Innovative biomaterial-based and advanced engineering-based approaches have been incorporated into conventional organoid culture methods to facilitate research development.
Recent advances in 3D cell culture technology have enabled scientists to generate stem cell derived organoids that recapitulate the structural and functional characteristics of native organs. Current organoid technologies have been striding toward identifying the essential factors for controlling the processes involved in organoid development, including physical cues and biochemical signaling. There is a growing demand for engineering dynamic niches characterized by conditions that resemble in vivo organogenesis to generate reproducible and reliable organoids for various applications. Innovative biomaterial-based and advanced engineering-based approaches have been incorporated into conventional organoid culture methods to facilitate the development of organoid research. The recent advances in organoid engineering, including extracellular matrices and genetic modulation, are comprehensively summarized to pinpoint the parameters critical for organ-specific patterning. Moreover, perspective trends in developing tunable organoids in response to exogenous and endogenous cues are discussed for next-generation developmental studies, disease modeling, and therapeutics.
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