4.8 Article

Facilitating In Situ Tumor Imaging with a Tetrahedral DNA Framework-Enhanced Hybridization Chain Reaction Probe

Related references

Note: Only part of the references are listed.
Article Engineering, Environmental

Tetrahedral framework nucleic acids act as antioxidants in acute kidney injury treatment

Qi Zhang et al.

Summary: This study demonstrates that tetrahedral framework nucleic acids (tFNAs) exhibit protective effects by relieving oxidative stress and inhibiting apoptosis in treating rhabdomyolysis (RM)-AKI, showing promise as a novel class of antioxidative nanomaterials with excellent antioxidant efficiency, superior structure stability, preferential kidney accumulation, and good biocompatibility.

CHEMICAL ENGINEERING JOURNAL (2021)

Article Chemistry, Analytical

Encoding DNA Frameworks for Amplified Multiplexed Imaging of Intracellular microRNAs

Dan Zhu et al.

Summary: This study developed a method using rationally designed one-pot assembled multicolor tetrahedral DNA frameworks (TDFs) encoded with multicomponent nucleic acid enzymes (MNAzymes) for signal-amplified multiple miRNAs imaging in living cells with high sensitivity and selectivity.

ANALYTICAL CHEMISTRY (2021)

Article Biophysics

Direct detection of intracellular miRNA in living circulating tumor cells by tumor targeting nanoprobe in peripheral blood

Chang Xu et al.

Summary: This study successfully demonstrated in situ detection of miR-21 in living CTCs in unprocessed whole blood using a highly efficient tumor targeting nanoprobe, providing an efficient strategy for genomic analysis of living CTCs in whole blood.

BIOSENSORS & BIOELECTRONICS (2021)

Article Nanoscience & Nanotechnology

Tetrahedral Framework Nucleic Acid-Based Delivery of Resveratrol Alleviates Insulin Resistance: From Innate to Adaptive Immunity

Yanjing Li et al.

Summary: The tFNA-based delivery of resveratrol (RSB) can improve insulin sensitivity and alleviate inflammation in high-fat diet-fed mice by modulating immune responses and macrophage phenotype. The synthesized nanoparticles, tFNAs-RSV, show potential as a therapeutic approach for treating insulin resistance and obesity-related metabolic diseases by targeting immune cell activation and inflammation.

NANO-MICRO LETTERS (2021)

Article Chemistry, Multidisciplinary

Tetrahedral Framework Nucleic Acids Induce Immune Tolerance and Prevent the Onset of Type 1 Diabetes

Shaojingya Gao et al.

Summary: The study showed that tetrahedral framework nucleic acids (tFNAs) treatment in NOD mice can induce immune tolerance, protect beta cells, and prevent the onset of type 1 diabetes (T1D) by immunomodulation.

NANO LETTERS (2021)

Article Chemistry, Multidisciplinary

Treating LRRK2-Related Parkinson's Disease by Inhibiting the mTOR Signaling Pathway to Restore Autophagy

Weitong Cui et al.

Summary: Vitamin B12 is a promising therapeutic option for Parkinson's disease (PD) due to its ability to inhibit LRRK2 activity, but its therapeutic effects are limited by transporter dependence and low brain tissue utilization. Researchers have synthesized VB12-loaded tetrahedral framework nucleic acid (TVC), which has shown to provide better recovery of autophagy and improvement of symptoms in PD models, indicating broad therapeutic potential for PD and similar neurodegenerative diseases.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Chemistry, Multidisciplinary

The Neuroprotective Effect of MicroRNA-22-3p Modified Tetrahedral Framework Nucleic Acids on Damaged Retinal Neurons Via TrkB/BDNF Signaling Pathway

Jiajie Li et al.

Summary: The study demonstrated that tetrahedral frame nucleic acids (tFNAs) - modified miR-22 can effectively treat glaucoma by activating the TrkB-BDNF signaling pathway to restore damaged retinal neurons' protective function.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Chemistry, Multidisciplinary

Therapeutic siCCR2 Loaded by Tetrahedral Framework DNA Nanorobotics in Therapy for Intracranial Hemorrhage

Wei Fu et al.

Summary: Inhibition of CCR2 expression during the acute phase of ICH polarizes microglia towards a therapeutic subtype, leading to accelerated hematoma absorption, decreased neurological inflammation, and improved neurological function in mice. The nanorobotic tFNA shows promising ability to transfer siCCR2 for treating ICH.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Chemistry, Multidisciplinary

Imaging of Cancer Cells and Dictated Cytotoxicity Using Aptamer-Guided Hybridization Chain Reaction (HCR)-Generated G-Quadruplex Chains

Amily Fang-Ju Jou et al.

Summary: DNA nanotechnology provides a powerful tool for developing cancer theranostics, with autonomous surface-nucleolin-guided HCR leading to the formation of Zn-II PPIX-loaded G-quadruplex polymer chains for selective imaging and cytotoxicity towards TNBC. This method offers a promising platform for targeting TNBC, which has poor prognosis and high risk of recurrence.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Review Gastroenterology & Hepatology

Early detection of pancreatic cancer using DNA-based molecular approaches

Aatur D. Singhi et al.

Summary: This review focuses on the pathological and molecular features of precancerous lesions of the pancreas, discussing the clinical significance and methods of using DNA-based molecular approaches for early detection of pancreatic cancer. With advancements in genetic analysis techniques, these methods hold promise for improving survival in patients with this disease.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

Article Engineering, Biomedical

Erythromycin loaded by tetrahedral framework nucleic acids are more antimicrobial sensitive against Escherichia coli (E. coli)

Yue Sun et al.

Summary: The study investigated the use of tFNAs as a delivery vehicle for erythromycin into Escherichia coli, showing that tFNAs can enhance bacterial uptake of the drug and promote membrane destabilization, ultimately reducing drug resistance. This novel delivery system may provide an effective way to target antibiotic-resistant bacteria with thick cell walls.

BIOACTIVE MATERIALS (2021)

Article Chemistry, Multidisciplinary

A Framework Nucleic Acid Based Robotic Nanobee for Active Targeting Therapy

Taoran Tian et al.

Summary: The tFNA nanostructure mimicking the natural reaction of honeybees to dangers achieves active targeting therapy, leading to enhanced selective cytotoxicity against tumor cells.

ADVANCED FUNCTIONAL MATERIALS (2021)

Review Oncology

Biomarker-guided therapy for colorectal cancer: strength in complexity

Anita Sveen et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

Article Biophysics

Hybridization chain reaction (HCR) for amplifying nanopore signals

Hong Sun et al.

BIOSENSORS & BIOELECTRONICS (2020)

Article Multidisciplinary Sciences

Implementing digital computing with DNA-based switching circuits

Fei Wang et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Hybridization Chain Reactions Targeting the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Tzu-Heng Wu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Materials Science, Multidisciplinary

In vivo serum enabled production of ultrafine nanotherapeutics for cancer treatment

Qingxin Mu et al.

MATERIALS TODAY (2020)

Article Oncology

Cancer statistics for adolescents and young adults, 2020

Kimberly D. Miller et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Review Chemistry, Multidisciplinary

The Recent Development of Hybridization Chain Reaction Strategies in Biosensors

Chuyan Zhang et al.

ACS SENSORS (2020)

Article Biochemistry & Molecular Biology

Tetrahedral framework nucleic acids promote scarless healing of cutaneous wounds via the AKT-signaling pathway

Junyao Zhu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Article Cell & Tissue Engineering

Effects of tetrahedral framework nucleic acid/wogonin complexes on osteoarthritis

Shi Sirong et al.

BONE RESEARCH (2020)

Article Materials Science, Multidisciplinary

Advances in biological applications of self-assembled DNA tetrahedral nanostructures

Songhang Li et al.

MATERIALS TODAY (2019)

Review Chemistry, Multidisciplinary

Principles and Applications of Nucleic Acid Strand Displacement Reactions

Friedrich C. Simmel et al.

CHEMICAL REVIEWS (2019)

Article Multidisciplinary Sciences

Framework nucleic acids as programmable carrier for transdermal drug delivery

Christian Wiraja et al.

NATURE COMMUNICATIONS (2019)

Review Chemistry, Multidisciplinary

Evolution of Hybridization Probes to DNA Machines and Robots

Dmitry M. Kolpashchikov

ACCOUNTS OF CHEMICAL RESEARCH (2019)

Article Nanoscience & Nanotechnology

PEGylated Protamine-Based Adsorbing Improves the Biological Properties and Stability of Tetrahedral Framework Nucleic Acids

Yichen Ge et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

Review Biochemical Research Methods

Cancer biomarker discovery and translation: proteomics and beyond

Ventzislava A. Hristova et al.

EXPERT REVIEW OF PROTEOMICS (2019)

Article Chemistry, Multidisciplinary

Localized DNA Hybridization Chain Reactions on DNA Origami

Hieu Bui et al.

ACS NANO (2018)

Review Chemistry, Multidisciplinary

Chemical and Biological Sensing Using Hybridization Chain Reaction

Erik E. Augspurger et al.

ACS SENSORS (2018)

Article Biochemical Research Methods

Modified Pearson correlation coefficient for two-color imaging in spherocylindrical cells

Sonisilpa Mohapatra et al.

BMC BIOINFORMATICS (2018)

Article Cell Biology

99mTc-HYNIC-(tricine/EDDA)-FROP peptide for MCF-7 breast tumor targeting and imaging

Sajjad Ahmadpour et al.

JOURNAL OF BIOMEDICAL SCIENCE (2018)

Article Chemistry, Multidisciplinary

Design and Analysis of Localized DNA Hybridization Chain Reactions

Hieu Bui et al.

SMALL (2017)

Review Chemistry, Multidisciplinary

Hybridization chain reaction: a versatile molecular tool for biosensing, bioimaging, and biomedicine

Sai Bi et al.

CHEMICAL SOCIETY REVIEWS (2017)

Article Engineering, Biomedical

Gene regulation with carbon-based siRNA conjugates for cancer therapy

Lingmin Zhang et al.

BIOMATERIALS (2016)

Review Chemistry, Multidisciplinary

Cancer biomarker detection: recent achievements and challenges

Li Wu et al.

CHEMICAL SOCIETY REVIEWS (2015)

Article Chemistry, Multidisciplinary

Electrostatic Nucleic Acid Nanoassembly Enables Hybridization Chain Reaction in Living Cells for Ultrasensitive mRNA Imaging

Zhan Wu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

Review Chemistry, Multidisciplinary

Diagnostic Applications Applications of Nucleic Acid Circuits

Cheulhee Jung et al.

ACCOUNTS OF CHEMICAL RESEARCH (2014)

Article Multidisciplinary Sciences

Visualization of Dynamics of Single Endogenous mRNA Labeled in Live Mouse

Hye Yoon Park et al.

SCIENCE (2014)

Article Biochemical Research Methods

A superfolding Spinach2 reveals the dynamic nature of trinucleotide repeat-containing RNA

Rita L. Strack et al.

NATURE METHODS (2013)

Article Biochemical Research Methods

A transgenic mouse for in vivo detection of endogenous labeled mRNA

Timothee Lionnet et al.

NATURE METHODS (2011)

Article Multidisciplinary Sciences

Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication

RP Goodman et al.

SCIENCE (2005)

Article Multidisciplinary Sciences

Triggered amplification by hybridization chain reaction

RM Dirks et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)