Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 32, Issue 2, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202107433
Keywords
germanium telluride; inflammatory bowel disease; multimodal imaging; nanosheets; oral administration; theranostics
Categories
Funding
- Korean Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI14C1324]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science and ICT, Republic of Korea [2020R1A202011942, 2020R1A2C1006092]
- Ministry of Education [2019R1I1A1A01064332]
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Recent studies have shown that 2D germanium telluride nanosheets coated with polyvinylpyrrolidone (PVP) have potential applications in nanomedicine for multispectral optoacoustic tomography and fluorescence imaging and therapy of inflammatory bowel disease. These nanosheets exhibit broad optical absorption in visible and near-infrared ranges, providing deeper tissue images than other materials. Additionally, when orally administered, they show therapeutic efficacy similar to or higher than traditional medication for inflammatory diseases in the gastrointestinal tract.
Recently, 2D nanomaterials have received considerable attention in nanomedicine due to their intrinsic optical properties, biocompatibility, and therapeutic effect. Here, 2D germanium telluride (GeTe) nanosheets coated with polyvinylpyrrolidone (PVP) (GeTe-PVP NSs) developed as theranostic agents are reported that can be used for multispectral optoacoustic tomography (MSOT) and fluorescence imaging and therapy of inflammatory bowel disease (IBD). GeTe-PVP NSs, fabricated by simple sonication in ethanol and PVP, show broad optical absorption in visible and near-infrared (NIR) ranges (400-1200 nm) and have intrinsic fluorescence properties. Thus, they provide deeper ex vivo and in vivo MSOT tissue images than gold nanorods or indocyanine green with strong optical absorption in the first NIR window (700-900 nm). In addition, when orally administered to IBD mice, GeTe-PVP NSs exhibit therapeutic efficacy similar to or higher than sulfasalazine, with strong accumulation at inflammatory colon sites. This demonstrates that oral administration of GeTe-PVP NSs may be used to treat inflammatory diseases in the gastrointestinal tract.
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