Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 177, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.addr.2021.113959
Keywords
Machine learning; Deep learning; Tumor models; Immunohistochemistry; Digital pathology; Tumor microenvironment
Categories
Ask authors/readers for more resources
Cancer is the leading cause of death globally, with efforts to understand the complex and heterogeneous tumor microenvironment (TME) being crucial for research into this disease. Utilizing in vitro tumor models and artificial intelligence to study the TME holds great potential, but faces limitations such as inadequate data and ethical concerns. Overcoming these limitations is essential for future research to improve clinical outcomes.
Cancer is the leading cause of death worldwide. Unfortunately, efforts to understand this disease are confounded by the complex, heterogenous tumor microenvironment (TME). Better understanding of the TME could lead to novel diagnostic, prognostic, and therapeutic discoveries. One way to achieve this involves in vitro tumor models that recapitulate the in vivo TME composition and spatial arrangement. Here, we review the potential of harnessing in vitro tumor models and artificial intelligence to delineate the TME. This includes (i) identification of novel features, (ii) investigation of higher-order relationships, and (iii) analysis and interpretation of multiomics data in a (iv) holistic, objective, reproducible, and efficient manner, which surpasses previous methods of TME analysis. We also discuss limitations of this approach, namely inadequate datasets, indeterminate biological correlations, ethical concerns, and logistical constraints; finally, we speculate on future avenues of research that could overcome these limitations, ultimately translating to improved clinical outcomes. (c) 2021 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available