Journal
ADDICTION BIOLOGY
Volume 27, Issue 2, Pages -Publisher
WILEY
DOI: 10.1111/adb.13134
Keywords
drug seeking; extinction; MRI; opioid; traumatic brain injury
Categories
Funding
- Advancing a Healthier Wisconsin
- National Institute on Drug Abuse [DA039276]
- U.S. Department of Veterans Affairs [RX002931]
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This study found interactive effects of traumatic brain injury (TBI) and oxycodone exposure on structural and functional neuroimaging measures, as well as correlational effects with drug seeking behavior. These findings suggest that TBI and opioid exposure may contribute to neuroadaptation associated with addiction liability.
Traumatic brain injury (TBI) and drug addiction are common comorbidities, but it is unknown if the neurological sequelae of TBI contribute to this relationship. We have previously reported elevated oxycodone seeking after drug self-administration in rats that received repeated blast TBI (rbTBI). TBI and exposure to drugs of abuse can each change structural and functional neuroimaging outcomes, but it is unknown if there are interactive effects of injury and drug exposure. To determine the effects of TBI and oxycodone exposure, we subjected rats to rbTBI and oxycodone self-administration and measured drug seeking and several neuroimaging measures. We found interactive effects of rbTBI and oxycodone on fractional anisotropy (FA) in the nucleus accumbens (NAc) and that FA in the medial prefrontal cortex (mPFC) was correlated with drug seeking. We also found an interactive effect of injury and drug on widespread functional connectivity and regional homogeneity of the blood oxygen level dependent (BOLD) response, and that intra-hemispheric functional connectivity in the infralimbic medial prefrontal cortex positively correlated with drug seeking. In conclusion, rbTBI and oxycodone self-administration had interactive effects on structural and functional magnetic resonance imaging (MRI) measures, and correlational effects were found between some of these measures and drug seeking. These data support the hypothesis that TBI and opioid exposure produce neuroadaptations that contribute to addiction liability.
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