4.5 Review

Nonsense Suppression Therapy: An Emerging Treatment for Hereditary Skin Diseases

Journal

ACTA DERMATO-VENEREOLOGICA
Volume 102, Issue -, Pages -

Publisher

ACTA DERMATO-VENEREOLOGICA
DOI: 10.2340/actadv.v102.353

Keywords

readthrough; aminoglycosides; PTC124; nonsense-mediated decay; suppressor tRNA; hereditary skin diseases

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Funding

  1. National Natural Science Foundation of China [82003363]
  2. Changsha Municipal Natural Science Foundation [kq2007059]
  3. Hunan Provincial Natural Science Foundation of China [2021JJ40820]

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This article summarizes the current research status of nonsense suppression therapy for hereditary skin diseases and discusses the potential opportunities and challenges of applying new technologies related to nonsense suppression therapy to dermatology. Further research is needed to explore the potential of nonsense suppression therapy as a safer and more specific treatment strategy for hereditary skin diseases.
Nonsense mutations cause the premature termination of protein translation via premature termination codons (PTCs), leading to the synthesis of incomplete functional proteins and causing large numbers of genetic disorders. The emergence of nonsense suppression therapy is considered to be an effective method for the treatment of hereditary diseases, but its application in hereditary skin diseases is relatively limited. This review summarizes the current research status of nonsense suppression therapy for hereditary skin diseases, and discusses the potential opportunities and challenges of applying new technologies related to nonsense suppression therapy to dermatology. Further research is needed into the possible use of nonsense suppression therapy as a strategy for the safer and specific treatment of hereditary skin diseases.

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