Journal
ACTA BIOMATERIALIA
Volume 143, Issue -, Pages 159-172Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2022.02.004
Keywords
Zinc doped nano-hydroxyapatite; Cross-linking; Biogenic collagen membrane; Bio-degradation; Tissue integration
Funding
- National Natural Science Foundation of China [82071167, 82001095, 81970975, 81901055]
- China Postdoctoral Science Foundation [2021TQ0379]
- Guangdong Basic and Applied Basic Research Foundation [2021A1515110380]
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Incorporating zinc-doped nanohydroxyapatite (nZnHA) and cross-linking with alendronate can improve the performance of biogenic collagen membranes, increasing their degradation period and providing good biocompatibility and tissue integration capability.
Biogenic collagen membranes have been widely used as soft tissue barriers in guided bone regeneration (GBR) and guided tissue regeneration (GTR). Nevertheless, their clinical performance remains unsatisfactory because of their low mechanical strength and fast degradation rate in vivo . Although cross-linking with chemical agents is effective and reliable for prolonging the degradation time of collagen membranes, some adverse effects including potential cytotoxicity and undesirable tissue integration have been observed during this process. As a fundamental nutritional trace element, zinc plays an active role in promoting the growth of cells and regulating the degradation of the collagen matrix. Herein, a biogenic collagen membrane was cross-linked with glutaraldehyde-alendronate to prolong its degradation time. The physiochemical and biological properties were enhanced by the incorporation of zinc-doped nanohydroxyapatite (nZnHA), with the native structure of collagen preserved. Specifically, the cross-linking combined with the incorporation of 1% and 2% nZnHA seemed to endow the membrane with the most appropriate biocompatibility and tissue integration capability among the cross-linked membranes, as well as offering a degradation period of six weeks in a rat subcutaneous model. Thus, improving the clinical performance of biogenic collagen membranes by cross-linking together with the incorporation of nZnHA is a promising strategy for the improvement of biogenic collagen membranes.
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