Journal
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
Volume 54, Issue 2, Pages 163-172Publisher
SCIENCE PRESS
DOI: 10.3724/abbs.2021016
Keywords
diabetes; diabetic nephropathy; epigenetics; metabolic memory
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Funding
- National Science Foundation of China [81871590]
- Shanghai Sailing Program [20YF1407800]
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This review discusses the important role of epigenetics in diabetic nephropathy, which affects the progression of the disease through various mechanisms and ultimately leads to a poor prognosis.
Diabetic nephropathy (DN), which is a common microvascular complication with a high incidence in diabetic patients, greatly increases the mortality of patients. With further study on DN, it is found that epigenetics plays a crucial role in the pathophysiological process of DN. Epigenetics has an important impact on the development of DN through a variety of mechanisms, and promotes the generation and maintenance of metabolic memory, thus ultimately leading to a poor prognosis. In this review we discuss the methylation of DNA, modification of histone, and regulation of non-coding RNA involved in the progress of cell dysfunction, inflammation and fibrosis in the kidney, which ultimately lead to the deterioration of DN.
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