Journal
ACS NANO
Volume 16, Issue 1, Pages 431-452Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.1c07205
Keywords
nanoenzyme; endoplasmic reticulum stress; oxidative damage; superoxide dismutase; ischemic stroke
Categories
Funding
- National Natural Science Foundation of China [32171296, 21877049, 81901200, 81671167]
- Major Program for Tackling Key Problems of Industrial Technology in Guangzhou [201902020013]
- Dedicated Fund for Promoting High-Quality Marine Economic Development in Guangdong Province [2020-035]
- Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation [201905010003]
- Innovation Team Project in Guangdong Colleges and Universities [2019KCXTD008]
- Science and Technology Program of Guangzhou [202002030425, 202002020003]
- K. C. Wong Education Foundation
- Special Funds for the Cultivation of Guangdong College Students' Scientific and Technological Innovation [pdjh2021b0059]
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This study designed a translational antioxidative agent, HSA-Mn3O4, which effectively inhibits nervous system damage caused by ischemic stroke reperfusion, demonstrating neuroprotective capacity mainly by inhibiting apoptosis and endoplasmic reticulum stress to prevent brain tissue damage.
Designing translational antioxidative agents that could scavenge free radicals produced during reperfusion in brain ischemia stroke and alleviate neurologic damage is the main objective for ischemic stroke treatment. Herein, we explored and simply synthesized a biomimic and translational Mn3O4 nanoenzyme (HSA-Mn3O4) to constrain ischemic stroke reperfusion-induced nervous system injury. This nanosystem exhibits reduced levels of inflammation and prolonged circulation time and potent ROS scavenging activities. As expected, HSA-Mn3O4 effectively inhibits oxygen and glucose deprivation-mediated cell apoptosis and endoplasmic reticulum stress and demonstrates neuroprotective capacity against ischemic stroke and reperfusion injury of brain tissue. Furthermore, HSA-Mn3O4 effectively releases Mn ions and promotes the increase of superoxide dismutase 2 activity. Therefore, HSA-Mn3O4 inhibits brain tissue damage by restraining cell apoptosis and endoplasmic reticulum stress in vivo. Taken together, this study not only sheds light on design of biomimic and translational nanomedicine but also reveals the neuroprotective action mechanisms against ischemic stroke and reperfusion injury.
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