Journal
ACS NANO
Volume 15, Issue 11, Pages 18048-18059Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.1c06651
Keywords
shape morphing; microrobot; magnetic actuation; laser printing; HeLa cell treatment
Categories
Funding
- National Natural Science Foundation of China [61927814, 91963127, 51675503, 51875544, 51805508, 51805509, 52075516, 62005262, 52005475]
- National Key R&D Program of China [2017YFB1104303, 2018YFB1105400]
- Major Scientific and Technological Projects in Anhui Province [201903a05020005]
- Fundamental Research Funds for the Central Universities [YD2090002005, WK2090050048, WK 2090000001]
- Youth Innovation Promotion Association CAS [2017495]
- Hong Kong Research Grants Council (RGC) [JLFS/E-402/18]
- CAS-Croucher Funding Scheme for Joint Laboratories [CAS20403]
- ITF project - HKSAR Innovation and Technology Commission (ITC) [MRP/036/18X]
- Multiscale Medical Robotics Center (MRC), InnoHK, at the Hong Kong Science Park
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The development of environmentally adaptive shape-morphing microrobots (SMMRs) with programmatically encoded expansion rates in pH-responsive hydrogel enables targeted microparticle delivery. Combining magnetic propulsion, a shape-morphing microcrab (SMMC) is capable of gripping, transporting, and releasing microparticles.
Microrobots have attracted considerable attention due to their extensive applications in microobject manipulation and targeted drug delivery. To realize more complex micro-/nanocargo manipulation (e.g., encapsulation and release) in biological applications, it is highly desirable to endow microrobots with a shape-morphing adaptation to dynamic environments. Here, environmentally adaptive shape-morphing microrobots (SMMRs) have been developed by programmatically encoding different expansion rates in a pH-responsive hydrogel. Due to a combination with magnetic propulsion, a shape-morphing microcrab (SMMC) is able to perform targeted microparticle delivery, including gripping, transporting, and releasing by opening-closing of a claw. As a proof-of-concept demonstration, a shape-morphing microfish (SMMF) is designed to encapsulate a drug (doxorubicin (DOX)) by closing its mouth in phosphate-buffered saline (PBS, pH similar to 7.4) and release the drug by opening its mouth in a slightly acidic solution (pH < 7). Furthermore, localized HeLa cell treatment in an artificial vascular network is realized by opening-closing of the SMMF mouth. With the continuous optimization of size, motion control, and imaging technology, these magnetic SMMRs will provide ideal platforms for complex microcargo operations and on-demand drug release.
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