4.6 Article

In Vitro and In Silico Analysis of the Residence Time of Serotonin 5-HT7 Receptor Ligands with Arylpiperazine Structure: A Structure- Kinetics Relationship Study

Related references

Note: Only part of the references are listed.
Article Chemistry, Medicinal

Privileged scaffold-based design to identify a novel drug-like 5-HT7 receptor-preferring agonist to target Fragile X syndrome

Enza Lacivita et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Article Pharmacology & Pharmacy

Revisit ligand-receptor interaction at the human vasopressin V 2 receptor: A kinetic perspective

Chunji Liu et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

Article Biochemistry & Molecular Biology

Ligand with Two Modes of Interaction with the Dopamine D2 Receptor-An Induced-Fit Mechanism of Insurmountable Antagonism

Richard Agren et al.

ACS CHEMICAL NEUROSCIENCE (2020)

Review Cell Biology

Binding kinetics of ligands acting at GPCRs

David A. Sykes et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2019)

Article Chemistry, Medicinal

Route to Prolonged Residence Time at the Histamine H1 Receptor: Growing from Desloratadine to Rupatadine

Reggie Bosma et al.

JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Neurosciences

Allosteric Inhibition of Serotonin 5-HT7 Receptors by Zinc Ions

Grzegorz Satala et al.

MOLECULAR NEUROBIOLOGY (2018)

Article Biochemistry & Molecular Biology

Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs

John D. McCorvy et al.

NATURE CHEMICAL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

GPCRdb in 2018: adding GPCR structure models and ligands

Gaspar Pandy-Szekeres et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Chemistry, Medicinal

Structure-Activity Relationships and Therapeutic Potentials of 5-HT7 Receptor Ligands: An Update

Maria N. Modica et al.

JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Chemistry, Multidisciplinary

Mordred: a molecular descriptor calculator

Hirotomo Moriwaki et al.

JOURNAL OF CHEMINFORMATICS (2018)

Article Chemistry, Medicinal

Prediction of Drug-Target Binding Kinetics by Comparative Binding Energy Analysis

Gaurav K. Ganotra et al.

ACS MEDICINAL CHEMISTRY LETTERS (2018)

Article Biotechnology & Applied Microbiology

A comprehensive map of molecular drug targets

Rita Santos et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Article Biochemistry & Molecular Biology

Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons

Luisa Speranza et al.

JOURNAL OF NEUROCHEMISTRY (2017)

Article Multidisciplinary Sciences

Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors

David A. Sykes et al.

NATURE COMMUNICATIONS (2017)

Review Pharmacology & Pharmacy

Kinetics for Drug Discovery: an industry-driven effort to target drug residence time

Doris A. Schuetz et al.

DRUG DISCOVERY TODAY (2017)

Article Biochemistry & Molecular Biology

Crystal Structure of an LSD-Bound Human Serotonin Receptor

Daniel Wacker et al.

Article Biotechnology & Applied Microbiology

The drug-target residence time model: a 10-year retrospective

Robert A. Copeland

NATURE REVIEWS DRUG DISCOVERY (2016)

Article Pharmacology & Pharmacy

Impact, determination and prediction of drug-receptor residence times for GPCRs

Christofer S. Tautermann

CURRENT OPINION IN PHARMACOLOGY (2016)

Review Pharmacology & Pharmacy

Can residence time offer a useful strategy to target agonist drugs for sustained GPCR responses?

J. Daniel Hothersall et al.

DRUG DISCOVERY TODAY (2016)

Article Chemistry, Medicinal

Toward High-Throughput Predictive Modeling of Protein Binding/Unbinding Kinetics

See Hong Chiu et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2016)

Review Pharmacology & Pharmacy

In vivo Target Residence Time and Kinetic Selectivity: The Association Rate Constant as Determinant

Wilhelmus E. A. de Witte et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2016)

Article Chemistry, Medicinal

Structure-Affinity Relationships (SARs) and Structure-Kinetics Relationships (SKRs) of Kv11.1 Blockers

Zhiyi Yu et al.

JOURNAL OF MEDICINAL CHEMISTRY (2015)

Article Multidisciplinary Sciences

Kinetics of protein-ligand unbinding: Predicting pathways, rates, and rate-limiting steps

Pratyush Tiwary et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Behavioral Sciences

Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics

Luisa Speranza et al.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2015)

Review Pharmacology & Pharmacy

Ligand Residence Time at G-protein-Coupled Receptors-Why We Should Take Our Time To Study It

C. Hoffmann et al.

MOLECULAR PHARMACOLOGY (2015)

Article Chemistry, Medicinal

Impact of Template Choice on Homology Model Efficiency in Virtual Screening

Krzysztof Rataj et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2014)

Review Chemistry, Medicinal

Drug-Target Residence Time-A Case for G Protein-Coupled Receptors

Dong Guo et al.

MEDICINAL RESEARCH REVIEWS (2014)

Review Pharmacology & Pharmacy

Molecular determinants of drug-receptor binding kinetics

Albert C. Pan et al.

DRUG DISCOVERY TODAY (2013)

Review Pharmacology & Pharmacy

Pharmacokinetics and the drug-target residence time concept

Goran Dahl et al.

DRUG DISCOVERY TODAY (2013)

Article Pharmacology & Pharmacy

Slow receptor dissociation is not a key factor in the duration of action of inhaled long-acting ß2-adrenoceptor agonists

David A. Sykes et al.

BRITISH JOURNAL OF PHARMACOLOGY (2012)

Review Pharmacology & Pharmacy

Target-drug interactions: first principles and their application to drug discovery

Sara Nunez et al.

DRUG DISCOVERY TODAY (2012)

Article Biochemistry & Molecular Biology

Molecular properties affecting fast dissociation from the D2 receptor

Gary Tresadern et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2011)

Article Chemistry, Physical

Markov models of molecular kinetics: Generation and validation

Jan-Hendrik Prinz et al.

JOURNAL OF CHEMICAL PHYSICS (2011)

Article Neurosciences

LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor

Peter B. Hedlund et al.

NEUROSCIENCE LETTERS (2010)

Article Pharmacology & Pharmacy

Quantifying the association and dissociation rates of unlabelled antagonists at the muscarinic M3 receptor

Mark R. Dowling et al.

BRITISH JOURNAL OF PHARMACOLOGY (2006)