Journal
ACS CHEMICAL NEUROSCIENCE
Volume 13, Issue 3, Pages 288-295Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acschemneuro.1c00607
Keywords
Microglia; astrocyte; oligodendrocyte; Schwann cells; satellite glial cells; inflammatory pain
Funding
- National Natural Science Foundation of China [81260187, 81660199]
- Natural Science Foundation of Jiangxi Province [20202BAB206027]
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This article reviews the relationship and mechanisms between glial cells and inflammatory pain, and introduces the medicine composition that can effectively inhibit inflammatory pain. It provides new ideas for the study of pain mechanisms and treatment.
Inflammatory pain is the perception of noxious stimuli that occurs during inflammation or an immune response. Glial cells are widespread in the central and peripheral nervous systems, supporting and guiding the migration of neurons, participating in the immune response, forming the myelin sheath and blood-brain barrier, and maintaining the concentration of potassium ions outside nerve cells. Recent studies have shown that glial cells have a significant connection with the production and development of inflammatory pain. This article reviews the relationship, mechanisms, therapeutic targets between five types of glial cells and inflammatory pain, and the medicine composition that can effectively inhibit inflammatory pain. It expands the study on the mechanism of glial cells regulating pain and provides new ideas for the therapy of inflammatory pain.
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