4.6 Review

Activity-Based Diagnostics: Recent Advances in the Development of Probes for Use with Diverse Detection Modalities

Journal

ACS CHEMICAL BIOLOGY
Volume 17, Issue 2, Pages 281-291

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acschembio.1c00753

Keywords

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Funding

  1. National Institutes of Health [R01 EB028628, R33 AI127581]

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This review highlights recent methodologies employed in activity-based diagnostics for detecting various diseases by leveraging the dysregulated enzyme expression and activity. These methods exhibit exquisite signal sensitivity and specificity in complex biological systems, and some have advanced into clinical trials.
Abnormal enzyme expression and activity is a hallmark of many diseases. Activity-based diagnostics are a class of chemical probes that aim to leverage this dysregulated metabolic signature to produce a detectable signal specific to diseased tissue. In this Review, we highlight recent methodologies employed in activity-based diagnostics that provide exquisite signal sensitivity and specificity in complex biological systems for multiple disease states. We divide these examples based upon their unique signal readout modalities and highlight those that have advanced into clinical trials.

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