Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 14, Issue 9, Pages 11144-11155Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c25014
Keywords
cationic hydrogels; inherent antimicrobial; hemostasis; wound healing; inflammation
Funding
- National Natural Science Foundation of China [51702161]
- Natural Science Foundation of Zhejiang Province [LQ22E030011]
- Wenzhou Medical University [KYYW201906]
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This study developed a new efficient synthetic strategy to prepare cationic hydrogels (PHCI) with intrinsic antimicrobial properties. In vivo experiments confirmed that the PHCI hydrogel can promote wound healing.
Bacterial infections are a common problem associated with wound treatment that imposes a significant burden on healthcare systems and patients. As a result, healthcare providers urgently need new treatment strategies to protect people. Hydrogel biomaterials with inherent antimicrobial properties offer an attractive and viable solution to this issue. Here, for the first time, we have developed a new efficient synthetic strategy to prepare cationic hydrogels (PHCI) with intrinsically efficient antimicrobial properties by chemically cross-linking trans-1,4-cyclohexanediamine with 1,3-dibromo-2-propanol using a condensation reaction without the use of toxic cross-linking agents. As expected, the prepared PHCI hydrogel possessed an inherent antibacterial ability that can adsorb and kill Staphylococcus aureus and Escherichia coli electrostatically. Notably, in vivo experiments on normal and diabetic rat models confirmed that the PHCI hydrogel can quickly stop bleeding, efficiently kill bacteria, promote the conversion of macrophages from the proinflammatory M1 phenotype to the repaired M2 phenotype, and accelerate collagen deposition and blood vessel formation, thereby achieving rapid wound healing. Overall, this work presents an effective antibacterial dressing that might provide a facile but effective approach for clinical wound management.
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