4.8 Article

Antibacterial Honeycomb Scaffolds for Achieving Infection Prevention and Bone Regeneration

Related references

Note: Only part of the references are listed.
Article Chemistry, Medicinal

No-Observed-Effect Level of Silver Phosphate in Carbonate Apatite Artificial Bone on Initial Bone Regeneration

Masaya Shimabukuro et al.

Summary: Fracture-related infections require treatments targeting bacteria removal and bone reconstruction. The use of Ag3PO4 in CO(3)Ap artificial bone at 0.1 wt% level demonstrated antibacterial effects without adverse effects, while higher concentrations caused inflammation.

ACS INFECTIOUS DISEASES (2022)

Article Engineering, Biomedical

Ionized jet deposition of antimicrobial and stem cell friendly silver-substituted tricalcium phosphate nanocoatings on titanium alloy

Gabriela Graziani et al.

Summary: This study demonstrates that nanostructured antibacterial and bioactive thin films obtained by Ionized Jet Deposition show promising potential for orthopedic implant applications, with significant antimicrobial efficacy against various bacterial strains and fungus while maintaining good biocompatibility. The deposition process allows for fine control over film composition and morphology, and the coatings exhibit suitable mechanical properties for implant integration.

BIOACTIVE MATERIALS (2021)

Article Engineering, Biomedical

Reconstruction of critical-size segmental defects in rat femurs using carbonate apatite honeycomb scaffolds

Yuta Sakemi et al.

Summary: The study introduced honeycomb scaffolds containing carbonate apatite for bone reconstruction in orthopedic surgery, demonstrating comparable efficacy to protein and cell scaffolds but at a lower cost and increased safety.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2021)

Review Materials Science, Multidisciplinary

Tailoring Scaffolds for Orthopedic Application With Anti-Microbial Properties: Current Scenario and Future Prospects

A. Preethi et al.

Summary: Research on orthopedic application focuses on designing advanced synthetic scaffolds with antimicrobial properties to prevent nosocomial infections and support tissue regeneration. Methods such as altering scaffold surfaces and incorporating antimicrobial compounds are utilized to inhibit microbial colonization while maintaining the scaffold's biocompatibility and fostering new bone formation. Various antimicrobial polymers and compounds found in nature can be incorporated into the scaffold without compromising its bioactivity for orthopedic applications.

FRONTIERS IN MATERIALS (2021)

Review Orthopedics

Review of calcium-sulphate-based ceramics and synthetic bone substitutes used for antibiotic delivery in PJI and osteomyelitis treatment

Razvan Ene et al.

Summary: Infection in orthopedic and trauma surgery is a challenging complication, and local antibiotic delivery using calcium sulfate as a biomaterial is increasingly popular due to its predictable release kinetics and good biocompatibility. Various commercially available antibiotic-delivery systems based on calcium sulfate are being investigated and used in clinical practice for the treatment and prevention of surgical site and implant-associated infections.

EFORT OPEN REVIEWS (2021)

Article Chemistry, Physical

Silver Decorated βTCP-Poly(3hydroxybutyrate) Scaffolds for Bone Tissue Engineering

Joanna Czechowska et al.

Summary: Silver-coated beta tricalcium phosphate porous scaffolds were prepared in this study, showing promising performance for bone tissue regeneration in non-load bearing applications. Materials coated with the biopolymer P(3HB) exhibited higher compressive strength and surgical maneuverability, with the sintering temperature affecting the physicochemical properties of the scaffolds.

MATERIALS (2021)

Article Materials Science, Multidisciplinary

Honeycomb scaffolds capable of achieving barrier membrane-free guided bone regeneration

Koichiro Hayashi et al.

Summary: The carbonate apatite honeycomb scaffolds can enhance bone growth and prevent soft tissue invasion by controlling the aperture size of the channels.

MATERIALS ADVANCES (2021)

Article Nanoscience & Nanotechnology

Honeycomb Scaffold-Guided Bone Reconstruction of Critical-Sized Defects in Rabbit Ulnar Shafts

Keigo Shibahara et al.

Summary: The study evaluated the ability of CAp HC scaffolds by reconstructing segmental defects in the rabbit ulnar shaft, showing that the scaffolds promoted bony callus formation at 4 weeks post-surgery and connected to the host bone at 12 weeks post-surgery in 10 and 15 mm defects. The results indicate that CAp HC scaffolds have good potential value for the reconstruction of critical-sized defects.

ACS APPLIED BIO MATERIALS (2021)

Article Nanoscience & Nanotechnology

Honeycomb Scaffolds Fabricated Using Extrusion Molding and the Sphere-Packing Theory for Bone Regeneration

Koichiro Hayashi et al.

Summary: The study fabricated three types of honeycomb scaffolds using carbonate apatite, with varying channel sizes to investigate the correlation between channel size and angiogenesis and osteogenesis. Results showed that increasing channel size significantly enhanced angiogenesis and bone tissue formation within the scaffolds, indicating the importance of channel size in bone regeneration.

ACS APPLIED BIO MATERIALS (2021)

Article Chemistry, Applied

Formation of calcium hydroxyapatite with high concentration of homogeneously distributed silver

Inga Grigoraviciute-Puroniene et al.

MICROPOROUS AND MESOPOROUS MATERIALS (2020)

Review Nanoscience & Nanotechnology

Advances in dual functional antimicrobial and osteoinductive biomaterials for orthopaedic applications

Samson Afewerki et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2020)

Review Engineering, Biomedical

Biomaterials against Bone Infection

Maria Vallet-Regi et al.

ADVANCED HEALTHCARE MATERIALS (2020)

Article Materials Science, Ceramics

Characterization, bioactivity and antimicrobial properties of a metal-ceramic composite for bone regeneration

Madeeha Riaz et al.

CERAMICS INTERNATIONAL (2020)

Article Materials Science, Biomaterials

Effects of macropore size in carbonate apatite honeycomb scaffolds on bone regeneration

Koichiro Hayashi et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

Article Engineering, Biomedical

Antibacterial calcium phosphate composite cements reinforced with silver-doped magnesium phosphate (newberyite) micro-platelets

Prabaha Sikder et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2020)

Article Materials Science, Biomaterials

Carbonate Apatite Micro-Honeycombed Blocks Generate Bone Marrow-Like Tissues as well as Bone

Koichiro Hayashi et al.

ADVANCED BIOSYSTEMS (2019)

Article Materials Science, Biomaterials

Synthesis of monophasic Ag doped hydroxyapatite and evaluation of antibacterial activity

Madeeha Riaz et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

Article Materials Science, Biomaterials

Silver doped resorbable tricalcium phosphate scaffolds for bone graft applications

Sean Hoover et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

Review Orthopedics

Infection following fractures of the proximal tibia - a systematic review of incidence and outcome

Ralf Henkelmann et al.

BMC MUSCULOSKELETAL DISORDERS (2017)

Article Materials Science, Ceramics

Functionalized silver doped hydroxyapatite scaffolds for controlled simultaneous silver ion and drug delivery

Arita Dubnika et al.

CERAMICS INTERNATIONAL (2017)

Article Materials Science, Ceramics

Silver-containing calcium phosphate materials of marine origin with antibacterial activity

C. Piccirillo et al.

CERAMICS INTERNATIONAL (2015)