Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 14, Issue 2, Pages 2650-2662Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c23174
Keywords
upconversion nanoparticles; mesoporous tin dioxide; nanocapsules; phototherapy; chemotherapy
Funding
- National Natural Science Foundation of China [NSFC 52002091]
- Heilongjiang Province Postdoctoral Foundation [LBH-Z19129]
- China Postdoctoral Science Foundation [2020M670884]
- Natural Science Foundation of Shandong Province [ZR2020ZD42]
- Fundamental Research funds for the Central Universities
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This study constructed pH/near-infrared dual-responsive nanotheranostics for cancer treatment using ultrasmall tin dioxide (SnO2) and upconversion nanoparticles (UCNPs). The nanocapsules exhibited improved drug delivery efficiency, inherent imaging performance, and high treatment efficiency through combining photodynamic therapy, hyperthermia effect, and chemotherapy. Additionally, the tin element in the nanocapsules served as a contrast agent for CT imaging. This study demonstrated the potential of nanocapsules for cancer treatment with excellent biocompatibility.
Smart nanotheranostic systems (SNSs) have attracted extensive attention in antitumor therapy. Nevertheless, constructing SNSs with disease diagnosis ability, improved drug delivery efficiency, inherent imaging performance, and high treatment efficiency remains a scientific challenge. Herein, ultrasmall tin dioxide (SnO2) was assembled with upconversion nanoparticles (UCNPs) to form mesoporous nanocapsules by an in situ hydrothermal deposition method, followed by loading with doxorubicin (DOX) and modification with bovine serum albumin (BSA). pH/near- infrared dual-responsive nanotheranostics was constructed for computed tomography (CT) and magnetic resonance (MR) imaging-induced collaborative cancer treatment. The mesoporous channel of SnO2 was utilized as a reservoir to encapsulate DOX, an antineoplastic drug, for chemotherapy and as a semiconductor photosensitizer for photodynamic therapy (PDT). Furthermore, the DOX-loaded UCNPs@SnO2-BSA nanocapsules combined PDT, Nd3+-doped UCNP-triggered hyperthermia effect, and DOX-triggered chemotherapy simultaneously and demonstrated prominently enhanced treatment efficiency compared to the monotherapy model. Moreover, tin, as one of the trace elements in the human body, has a similar X-ray attenuation coefficient to iodine and therefore can act as a contrast agent for CT imaging to monitor the treatment process. Such an orchestrated synergistic anticancer treatment exhibited apparent inhibition of tumor growth in tumor-bearing mice with negligible side effects. Our study demonstrates nanocapsules with excellent biocompatibility and great potential for cancer treatment.
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