Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 13, Issue 42, Pages 50246-50257Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c15067
Keywords
hypoxia-responsive; periodic mesoporous organosilica; Forster resonance energy transfer (FRET); controlled release; real-time monitoring
Funding
- National Key Research and Development Program of China [2019YFC1604601, 2019YFC1604600, 2017YFA0206901, 2017YFA0206900, 2018YFC1602301]
- National Natural Science Foundation of China [21705027, 21974029]
- Natural Science Foundation of Shanghai [18ZR1404700]
- Construction Project of Shanghai Key Laboratory of Molecular Imaging [18DZ2260400]
- Shanghai Municipal Education Commission (Class II Plateau Disciplinary Construction Program of Medical Technology of SUMHS)
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A hypoxia-responsive nanocarrier capable of repairing hypoxia damage and tracking drug release in real-time is reported. This nanosystem has the potential to simultaneously report and treat hypoxia conditions, highlighting its significance in the biomedical field.
Hypoxia, induced by inadequate oxygen supply, is a key indication of various major illnesses, which necessitates the need to develop new nanoprobes capable of sensing hypoxia environments for the targeted system monitoring and drug delivery. Herein, we report a hypoxia-responsive, periodic mesoporous organosilica (PMO) nanocarrier for repairing hypoxia damage. beta-cyclodextrin (beta-CD) capped azobenzene functionalization on the PMO surface could be effectively cleaved by azoreductase under a hypoxia environment. Moreover, the nanosystem is equipped with fluorescence resonance energy transfer (FRET) pair (tetrastyrene derivative (TPE) covalently attached to the PMO framework as the donor and Rhodamine B (RhB) in the mesopores as the receptor) for intracellular visualization and tracking of drug release in real-time. The design of intelligent nanocarriers capable of simultaneous reporting and treating of hypoxia conditions highlights a great potential in the biomedical domain.
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