Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 13, Issue 42, Pages 49581-49588Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c14275
Keywords
gold nanoclusters; theranostic agents; structure-property relationship; atomic precision; machine learning
Funding
- National Health and Medical Research Council (NHMRC) of Australia [GNT1112432]
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Quantum-sized gold nanoclusters are emerging as theranostic agents due to their molecule-like behavior and interesting properties, but scalable synthetic approaches and methods to determine their structure-property relationships for biological applications are still lacking. Further research is needed to propel gold nanoclusters as a preferred theranostic agent for biomedical applications.
Quantum-sized gold nanoclusters (AuNCs) are emerging as theranostic agents-those that combine diagnostics and therapeutic properties-given their ultrasmall size <3 nm, which makes them behave more like a molecule rather than a nanoparticle. This molecule-like behavior endows AuNCs with interesting properties including photoluminescence, catalytic activity, and paramagnetism-all without the presence of any toxic heavy metal. But despite these fundamental advances, scalable synthetic approaches to produce high-quality AuNCs with well-controlled and programmable properties for biological applications as well as methods to determine their structure- property relationships are not widely available. In this Perspective, we will discuss what is known so far about AuNCs as well as how to move forward to propel AuNCs as a theranostic agent of choice for many biomedical applications.
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