4.8 Article

Emitter-Quencher Pair of Single Atomic Co Sites and Monolayer Titanium Carbide MXenes for Luminol Chemiluminescent Reactions

Journal

ACS APPLIED MATERIALS & INTERFACES
Volume 13, Issue 51, Pages 60945-60954

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c20489

Keywords

Co single atomic site catalysts; titanium carbide MXenes; chemiluminescence quenching; immunochromatographic test strip

Funding

  1. National Natural Science Foundation of China [21804111, 22074123, 21775125]
  2. Natural Science Foundation of Chongqing [cstc2021jcyj-msxmX0248]
  3. Fundamental Research Funds for the Central Universities [SWU120077]

Ask authors/readers for more resources

A facile one-step doping method was used to synthesize Co single atomic site catalysts in UiO-66 metal-organic frameworks, leading to a significant enhancement in chemiluminescent emission. MXenes were shown to efficiently quench the emission signal of Co SASCs. The combination of Co SASCs and titanium carbide MXenes was successfully applied to develop an immunoassay method for detecting cardiac troponin I.
A facile, one-step doping protocol was adopted to synthesize Co single atomic site catalysts (SASCs) in UiO-66 metal-organic frameworks. In view of highly uniform active sites of Co-O-6 moieties, the SASCs specifically contribute to catalyzing the generation of a large amount of singlet oxygen instead of superoxide or hydroxyl radicals, which endows Co SASCs with a the remarkable enhancement effect (similar to 3775 times) on luminol chemiluminescent (CL) emission. Interestingly, monolayer titanium carbide MXenes can drastically quench the CL signal of the Co SASC-boosted luminol reaction by similar to 94.6% as highly efficient luminescent absorbents. Furthermore, the emitter-quencher pair of Co SASCs and titanium carbide MXenes was successfully adopted to develop an immunoassay method for cardiac troponin I (cTnI) on an immunochromatographic test strip platform. With a sandwich immunoreaction mode, a titanium carbide MXene-labeled cTnI tracer antibody was captured on the test line of a test strip, which significantly inhibited the CL response of the Co SACs-boosted luminol system. The dynamic range for quantitating cTnI is 1.0-100 pg mL(-1), with a detection limit of 0.33 pg mL(-1) (3 sigma). The test strip was successfully used to detect cTnI in human serum samples collected from cardiopathy patients. This proof-of-principle work manifests both the CL enhancement of SASCs and the quenching behavior of MXenes, which shows the thrilling prospects of combinational usage of the two functionalized nanomaterials for tracking biological recognition events.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available