Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 13, Issue 45, Pages 53541-53552Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c14216
Keywords
injectable conductive hydrogels; pH responsiveness; intrinsic antimicrobial property; wound healing; epidermal sensor
Funding
- Aeronautical Science Foundation of China [2018ZF53065]
- National Natural Science Foundation of China [21905228, 31900950]
- Fundamental Research Funds for the Central Universities [3102018zy047]
- Natural Science Basic Research Plan in Shaanxi Province of China [2017JQ2002]
- Shanghai Space Science and Technology Innovation Fund
- Innovative Training Program for College Students in Shaanxi Province [s201910699329]
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This study developed a chitosan-based hydrogel with self-healing, conductive, and antibacterial properties, which can be used as a sensor to monitor human health in real-time and promote wound healing. The injectable hydrogel, fabricated via Schiff base linkage and hydrogen bond, shows pH responsiveness and broad-spectrum antibacterial properties.
Torealize intelligent and personalized medicine, it is a huge challenge to develop a hydrogel dressing that can be used as a sensor to monitor human health in real-time while promoting wound healing. Herein, an injectable, self-healing, and conductive chitosan-based (CPT) hydrogel with pH responsiveness and intrinsic antibacterial properties was fabricated via a Schiff base linkage and a hydrogen bond. Due to the introduction of Schiff base bonds, the injectable CPT hydrogel exhibits various excellent properties, such as pH responsiveness to sol-gel transition, self-healing properties, and broad-spectrum antibacterial properties even without additional antibacterial agents. In vitro experiments verify the excellent biocompatibility of the as-prepared hydrogel. An in vivo experiment in a mouse full-thickness skin-wound model was performed to confirm the outstanding effect on wound healing. Meanwhile, as epidermal sensors, the conductive hydrogel that perceives various human activities in real-time could provide the real-time analysis of the patient's healthcare information. Based on these excellent properties, the CPT hydrogel, as a biological dressing with a sensing function, lays a solid foundation for the further realization of personalized medicine.
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