Oxygenic Enrichment in Hybrid Ruthenium Sulfide Nanoclusters for an Optimized Photothermal Effect

Transition-metal dichalcogenide (TMD)-based nanomaterials have been extensively explored for the photonic therapy. To the best of our knowledge, near-infrared (NIR) light is a requirement for the photothermal therapy (PTT) to achieve the feature of deep-tissue penetration, whereas no obvious absorption peaks existing in the NIR region for existing TMD nanomaterials limit their therapeutic efficacy. As one category of TMD nanomaterials, ruthenium sulfide-based nanomaterials have been less exploited in biomedical applications including tumor therapy so far. Here, we develop a facile biomineralization-assisted bottomup strategy to synthesize oxygenic hybrid ruthenium sulfide nanoclusters (RuSx NCs) by regulating the oxygen amounts and sulfur defects for the optimized PTT. By regulating the increasing initial molar ratios of Ru to S, RuSx NCs with small sizes were endowed with increasing oxygen contents and sulfur defects, leading to the photothermal conversion efficiency (PCE) increasing from 32.8 to 41.9%, which were higher than that of most small-sized inorganic photothermal nanoagents. In contrast to commercial indocyanine green, these RuSx NCs exhibited higher photostability under NIR laser irradiation. The high PCE and superior photostability allowed RuSx NCs to effectively and completely ablate cancer cells. Thus, the proposed defect engineering strategy endows RuSx NCs with an excellent photothermal effect for the PTT of tumors of living mice, which also proves the potential of further exploring the properties of RuSx NCs for future biomedical applications.

Automated summary

A biomineralization-assisted bottom-up strategy was developed to synthesize oxygenic hybrid ruthenium sulfide nanoclusters (RuSx NCs) with optimized photothermal therapy (PTT) by regulating oxygen amounts and sulfur defects. With increasing molar ratios of Ru to S, RuSx NCs demonstrated higher photothermal conversion efficiency (PCE) compared to most small-sized inorganic photothermal nanoagents. High PCE and superior photostability of RuSx NCs allowed for effective and complete cancer cell ablation, showing potential for future biomedical applications.