Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 13, Issue 47, Pages 55815-55826Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c15282
Keywords
carbon dot nanoclusters; cancer cell membrane; redox-responsiveness; fluorescence imaging; chemotherapy of tumors
Funding
- Science and Technology Commission of Shanghai Municipality [19XD1400100, 21490711500, 20520710300]
- National Natural Science Foundation of China [81761148028, 21773026]
- Fundamental Research Funds for the Central Universities and Graduate Student Innovation Fund of Donghua University [CUSF-DH-2021030]
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This study presents a unique strategy to design and prepare redox-responsive yellow fluorescent carbon dot nanoclusters for precise imaging and chemotherapy of tumors. The nanoclusters showed efficient fluorescence recovery and tumor penetration ability in the reductive tumor microenvironment, releasing doxorubicin for targeted chemotherapy. The designed nanoclusters may represent an advanced nanomedicine formulation for improved theranostics of different types of tumors.
Designing intelligent stimuli-responsive nanoplatforms that are integrated with a biological membrane system and nanomaterials to realize efficient imaging and therapy of tumors still remains to be challenging. Herein, we report a unique strategy to prepare redoxresponsive yellow fluorescent carbon dot nanoclusters (y-CDCs) loaded with anticancer drug doxorubicin (DOX) and coated with the cancer cell membrane (CCM) for precision fluorescence imaging and homologous targeting chemotherapy of tumors. The y-CDs with a size of 7.2 nm were first synthesized via a hydrothermal method and crosslinked to obtain redox-responsive y-CDCs with a size of 150.0 nm. The formulated y-CDCs were physically loaded with DOX with an efficiency of up to 81.0% and coated with CCM to endow them with antifouling properties, immune escape ability to escape from macrophage uptake, and homologous targeting capability to cancer cells. Within the reductive tumor microenvironment, the y-CDCs with quenched fluorescence can dissociate to form single y-CDs with recovered fluorescence and improved tumor penetration ability and simultaneously release DOX from the cluster bomb, thus realizing efficient targeted tumor fluorescence imaging and chemotherapy. The designed y-CDCs/DOX@CCM may represent an updated nanomedicine formulation based on CDs for improved theranostics of different types of tumors.
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