4.8 Article

In Situ Microfluidic SERS Chip for Ultrasensitive Hg2+ Sensing Based on I--Functionalized Silver Aggregates

Journal

ACS APPLIED MATERIALS & INTERFACES
Volume 14, Issue 1, Pages 2211-2218

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c17832

Keywords

Hg2+ sensing; surface-enhanced Raman scattering; microfluidic chip; in situ detection; photoreduction

Funding

  1. National Natural Science Foundation of China [11774245, 11704266, 11804237]
  2. Beijing Natural Science Foundation [Z190006]
  3. National Key Research and Development Program of China [2021YFA1400800]
  4. National Youth Talent Support Program
  5. Training Program of the Major Research Plan of Capital Normal University
  6. Postgraduates innovation project of Capital Normal University
  7. Scientific Research Base Development Program of Beijing Municipal Commission of Education
  8. Beijing Key Laboratory of Metamaterials and Devices

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A surface-enhanced Raman scattering (SERS) substrate functionalized with I- was developed for rapid and sensitive Hg2+ sensing on a microfluidic platform. The sensor demonstrated fast response, high sensitivity, and good selectivity towards Hg2+, with detectable concentrations as low as 1 fM. Real water sample detection showed promising results for on-site Hg2+ detection.
Mercury(II) ions are causing serious environmental pollution and health damage. Developing a simple, rapid, and sensitive sensor for Hg2+ detection is of great significance. Herein, we demonstrate an I--functionalized surface-enhanced Raman scattering (SERS) substrate for rapid and sensitive Hg2+ sensing on a highly integrated microfluidic platform. Based on the combination reaction between I- and Hg2+, the Hg2+ sensing is achieved via the SERS intensity turn-off strategy, where Hg2+ precipitation is formed on an SERS substrate interface, dissociating the Raman reporters that coadsorbed with I-. Owing to the strong binding constant between I- and Hg2+, our I--functionalized substrate demonstrates a very fast sensing response (similar to 150 s). Through reliable in situ SERS detection, a robust calibration curve between the turn-off' signal and IgC is obtained in a broad concentration range of 10(-)(9) to 10(-13) M. Additionally, the detectable Hg2+ concentration can be as low as 1 fM. The good selectivity toward Hg2+ is also verified by testing about a dozen common metal ions in water, such as K+, Na+, Ca2+, Mg2+, and so forth. Furthermore, we apply the SERS sensor for real tap and lake water sample detection, and good recoveries of 113, 97, and 107% are obtained. With its advantages of high integration, simple preparation, fast response, high sensitivity, and reliability, the proposed I--functionalized SERS sensor microfluidic chip can be a promising platform for real-time and on-site Hg2+ detection in natural water.

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