Journal
HYPERTENSION IN PREGNANCY
Volume 36, Issue 1, Pages 8-15Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10641955.2016.1217337
Keywords
Antiphospholipid syndrome; aspirin; hypertensive disorders of pregnancy; low-molecular-weight heparin; systemic lupus erythematosus
Funding
- Nationale Vereniging LE patienten (NVLE)
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Objective: To relate anticoagulant use to pregnancy complications in women with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS). Methods: All ongoing pregnancies, 184, in two Dutch tertiary centers between 2000 and 2015. Results: LMWH and aspirin was prescribed in 15/109 SLE women without antiphospholipid antibodies (aPL), 5/14 with aPL, 11/13 with APS, 45/48 with primary APS. Main complications in the four treatment groups (no anticoagulant treatment, aspirin, LMWH, aspirin and LMWH) included hypertensive disorders of pregnancy (9.4%, 23.3%, 50%, 18.4%, respectively, p = 0.12) and preterm birth (16.7%, 34.3%, 75%, 36.8%, respectively, p < 0.001). Conclusion: Maternal and perinatal complications occurred frequently, despite LMWH and aspirin use.
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