Journal
HYPERTENSION IN PREGNANCY
Volume 35, Issue 3, Pages 394-404Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/10641955.2016.1162315
Keywords
AGT; CALCA; candidate gene; DDAH1; DNA methylation; leukocyte; POMC; preeclampsia; pregnancy
Funding
- Mayo Clinic: Mary Kathryn and Michael B. Panitch Career Development Award
- Eunice Kennedy Shriver National Institute of Child Health and Human Development [K08 HD051714]
- Mayo Clinic Center for Individualized Medicine (CIM) Epigenomics Translational Program
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Objective: To analyze methylation profiles of known preeclampsia/eclampsia (PE) candidate genes in normal (NL) and preeclamptic (PE) women at delivery. Methods: A matched case-control study comparing methylation in 79 CpG sites/33 genes from an independent gene set in maternal leukocyte DNA in PE and NL (n = 14 each) on an Illumina BeadChip platform. Replication performed on second cohort (PE = 12; NL = 32). Results: PE demonstrates differential methylation in POMC, AGT, CALCA, and DDAH1 compared with NL. Conclusion: Differential methylation in four genes associated with PE may represent a potential biomarker or an epigenetic pathophysiologic mechanism altering gene transcription.
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