Journal
CCS CHEMISTRY
Volume 3, Issue 6, Pages 1596-1606Publisher
CHINESE CHEMICAL SOC
DOI: 10.31635/ccschem.020.202000383
Keywords
long term; lipid droplets tracking; tumor monitoring; near infrared; aggregation-induced emission
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Funding
- National Natural Science Foundation of China [21788102, 51673107]
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The new organic fluorescent nanoprobe TPATBT NPs demonstrates excellent bioimaging performance in living cells, with long-term tumor monitoring capabilities, as well as good biocompatibility and stability.
Effective real-time tumor monitoring and cell tracking are of great importance for precise diagnosis and therapy of tumors, and also for the surveillance of biological processes. In this study, a new organic fluorescent nanoprobe (named TPATBT NPs) with unique aggregation-induced emission (AIE) characteristics has been obtained for the first time via facile synthesis to achieve real-time and long-term monitoring in living cells. The advantages of TPATBT NPs include small size (similar to 80 nm), a large Stokes shift (similar to 150 nm), high stability, good dispersibility in aqueous media, and biocompatibility. In addition, such NPs have showed excellent bioimaging performance and unusual long-term tumor monitoring properties. The red fluorescence signals inside MDA-MB-231 cells last for longer than 10 generations (18 days). Moreover, the cellular uptake of TPATBT NPs has been found to highly rely on energy-dependent endocytosis and clathrin-mediated endocytosis, and to primarily accumulate in lipid droplets (LDs), which can lead to targeted LD cellular imaging and therapy. Thus, TPATBT NPs can work as an excellent fluorescent nanoprobe for long-term monitoring of malignant tumor growth and dynamic biological processes.
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