Spirocyclizative Remote Arylcarboxylation of Nonactivated Arenes with CO2 via Visible-Light-Induced Reductive Dearomatization

Visible-light-induced reductive dearomatization of nonactivated arenes is a very challenging transformation and remains in its infancy. Herein, we report a novel strategy to achieve a visible-light-induced spirocyclizative remote arylcarboxylation of nonactivated arenes including naphthalenyl- and phenyl-bearing aromatics with CO2 under mild conditions through a radical-polar crossover cascade (RPCC). This reductive dearomatization protocol rapidly delivers a broad range of spirocyclic and valuable carboxylic acid derivatives from readily accessible aromatic precursors with generally good regioselectivity and chemoselectivity. [GRAPHICS] .

Automated summary

In this paper, a novel strategy for visible-light-induced spirocyclizative remote arylcarboxylation of nonactivated arenes is reported. This transformation, achieved through a radical-polar crossover cascade, allows for the rapid synthesis of diverse spirocyclic and carboxylic acid derivatives from readily accessible aromatic precursors.