Journal
BRITISH JOURNAL OF PSYCHIATRY
Volume 206, Issue 2, Pages 164-165Publisher
ROYAL COLLEGE OF PSYCHIATRISTS
DOI: 10.1192/bjp.bp.113.142216
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Funding
- Medical Research Council (UK) [MC-A656-5QD30]
- National Institute of Health Research Biomedical Research Council
- Medical Research Council [MR/L011794/1, MC_U120097115, G0700995, 1116129] Funding Source: researchfish
- National Institute for Health Research [CL-2015-18-005, ACF-2014-18-010] Funding Source: researchfish
- MRC [MR/L011794/1, G0700995, MC_U120097115] Funding Source: UKRI
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N-methyl-D-aspartate receptor (NMDA-R) autoantibodies have been reported in people with acute psychosis. We hypothesised that their presence may be implicated in the aetiology of treatment-refractory psychosis. We sought to ascertain the point prevalence of NMDA-R antibody positivity in patients referred to services for treatment-refractory psychosis. We found that 3 (7.0%) of 43 individuals had low positive NMDA-R antibody titres. This suggests that NMDA-R autoantibodies are unlikely to account for a large proportion of treatment-refractory psychosis.
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