Journal
GENE REPORTS
Volume 24, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.genrep.2021.101240
Keywords
miRNA-410; HDAC1; Chemotherapy agents; Ovarian cell lines
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The study evaluated the effects of 5-Aza-dC, TSA, and Cisplatin on gene and miRNA expression in ovarian cancer cell lines. The findings suggest that the coadministration of these drugs has more effective results in this context.
The purpose of this study was in vitro evaluation of 5-Aza-2'-Deoxycytidine (5-Aza-dC), Trichostatin A (TSA) and Cisplatin effects on HDAC1 gene and miRNA-410 expression in ovarian cancer cell lines and comparing with cotreatment results on gene expression. Influence of 5-Aza-2'-Deoxycytidine, TSA and Cisplatin on human cells was evaluated alone and together. We measured HDAC gene and miR-410 expression by Quantitative Real Time polymerase chain reactions (qRT-PCR) and the results were analyzed by SPSS and GraphPad Prism 7 software. While each drug effects the expression of HDAC1 and miRNA-410, their coadministration had more effective results. Cisplatin, TSA, and 5-Aza-dC have a great potential in terms of therapeutic agents in ovarian cancer patients; however, more studies are needed to optimize their specificity and effectiveness.
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