3.8 Article

Polyphenol intake and cardiovascular risk in the PREDIMED-Plus trial. A comparison of different risk equations

Journal

REVISTA ESPANOLA DE CARDIOLOGIA
Volume 75, Issue 5, Pages 401-411

Publisher

EDICIONES DOYMA S A
DOI: 10.1016/j.rec.2021.06.013

Keywords

Polyphenols; Cardiovascular risk; Cardiovascular score

Funding

  1. official funding agency for biomedical research of the Spanish government, ISCIII, through the Fondo de Investigacio'n para la Salud (FIS)
  2. European Regional Development Fund [PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662]
  3. The European Regional Development Fund [PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309]
  4. 'European Regional Development Fund' [PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, CIBEROBN CB06/03, CB12/03]
  5. Especial Action Project entitled: Implementacion y evaluacion de una intervencio n intensiva sobre la actividad fisica Cohorte PREDIMED-Plus grant
  6. European Research Council [340918]
  7. Recercaixa Grant [2013ACUP00194]
  8. CICYT [AGL2016-75329-R]
  9. Generalitat Valenciana [APOSTD/2019/136, PROMETEO/2017/017]
  10. Generalitat de Catalunya [SGR-2019]
  11. Consejeria de Salud de la Junta de Andalucia [PI0458/2013, PS0358/2016, PI0137/2018]
  12. SEMERGEN Grant
  13. EU-COST Action [CA16112]
  14. European Commission [EAT2BENI-CE_H2020_SFS2016]
  15. Spanish Ministry of Science, Innovation and Universities [FPU17/06488, FPU17/00785]
  16. Balearic Islands Government [35/2011]
  17. Balearic Islands Health Research Institute (IDISBA)

Ask authors/readers for more resources

This study aimed to assess the association between intake of different classes of polyphenols and cardiovascular risk scores. The results showed that intake of polyphenols, except phenolic acids, was associated with a lower cardiovascular risk, especially among women.
Introduction and objectives: Quantification of cardiovascular risk has been based on scores such as Framingham, Framingham-REGICOR, SCORE or Life's Simple 7 (LS7). In vitro, animal, and randomized clinical studies have shown that polyphenols may provide benefits to the vascular system and reduce the inflammatory response. However, some clinical-epidemiological studies have yielded inconsistent results. Our aim was to assess the possible association between intake of the various polyphenol classes and established cardiovascular scores. Methods: This cross-sectional analysis involved 6633 PREDIMED-Plus study participants. Food polyphenol content was estimated by a semi-quantitative food frequency questionnaire, adjusted for total energy intake according to the residual method. The association between polyphenol intake and cardiovascular risk was tested using linear regression analyses. Results: Total polyphenol and flavonoid intake were directly and significantly associated only with the LS7 scale. Intake of lignans was directly and significantly associated with SCORE and LS7 scales, stilbene intake with SCORE, and phenolic acid intake with Framingham and Framingham-REGICOR scores. Other polyphenol classes were associated in a protective and significant manner in Framingham, SCORE and LS7 scores. In women, intake of all the polyphenol classes, except phenolic acids, showed a protective trend in the results of the Framingham, Framingham-REGICOR scores and LS7 scale. Conclusions: An inverse association was found between consumption of the 'other polyphenols' class and, especially among women, with estimated cardiovascular risk. The results were similar to those of Framingham, Framingham-REGICOR and LS7 (after eliminating the diet component) and differed from those of SCORE, but the predictors included were limited in the latter case. (C) 2021 Sociedad Espanola de Cardiologia. Published by Elsevier Espana, S.L.U. All rights reserved.

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