Journal
HUMAN BRAIN MAPPING
Volume 37, Issue 3, Pages 1080-1090Publisher
WILEY
DOI: 10.1002/hbm.23085
Keywords
treatment-resistant depression; ketamine; glucose; prefrontal cortex
Funding
- Ministry of Science and Technology, Taiwan [102-2314-B-010-060, 103-2314-B-075-072-MY3, 103-2325-B-039-005, 104-2325-B-039-004]
- Taipei veterans general hospital [VGHUST102-G4-3-1, VGHUST104-G4-1-2, V104E9-003]
Ask authors/readers for more resources
BackgroundLow-dose ketamine has been found to have robust and rapid antidepressant effects. A hypoactive prefrontal cortex (PFC) and a hyperactive amygdala have been suggested to be associated with treatment-resistant depression (TRD). However, it is unclear whether the rapid antidepressant mechanisms of ketamine on TRD involve changes in glutamatergic neurotransmission in the PFC and the amygdala. MethodsA group of 48 TRD patients were recruited and equally randomized into three groups (A: 0.5 kg/mg-ketamine; B: 0.2 kg/mg-ketamine; and C: normal saline [NS]). Standardized uptake values (SUV) of glucose metabolism measured by F-18-FDG positron-emission-tomography before and immediately after a 40-min ketamine or NS infusion were used for subsequent region-of-interest (ROI) analyses (a priori regions: PFC and amygdala) and whole-brain voxel-wise analyses and were correlated with antidepressant responses, as defined by the Hamilton depression rating scale score. The F-18-FDG signals were used as a proxy measure of glutamate neurotransmission. ResultsThe ROI analysis indicated that Group A and Group B, but not Group C, had increases in the SUV of the PFC (group-by-time interaction: F=7.373, P=0.002), whereas decreases in the SUV of the amygdala were observed in all three groups (main effect of time, P<0.001). The voxel-wise analysis further confirmed a significant group effect on the PFC (corrected for family-wise errors, P<0.05; post hoc analysis: Group A
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available