Immune thrombocytopenic purpura and acute liver injury after COVID-19 vaccine

A 26-year-old woman was sent to the emergency room by her primary care physician for a new petechial rash and thrombocytopenia 2 weeks after receiving the Moderna mRNA-1273 SARS-CoV-2 vaccine. Her hospital course was complicated by transaminitis. Her platelet count improved to normal on hospital day 5 after receiving intravenous steroids and intravenous immunoglobulin to treat her suspected diagnosis of immune thrombocytopenic purpura. Extensive workup for her thrombocytopenia and transaminitis was unremarkable including ruling out infectious, autoimmune and toxic causes. A liver biopsy was unrevealing and her transaminitis was improved on discharge. Although not proven, the temporal relationship of her vaccination with thrombocytopenia and abnormal liver enzymes points towards the Moderna mRNA-1273 SARS-CoV-2 vaccine as the most likely inciting factor.

Automated summary

A 26-year-old woman developed immune thrombocytopenic purpura and transaminitis 2 weeks after receiving the Moderna mRNA-1273 vaccine. Treatment with steroids and immunoglobulin led to improvement in platelet count and liver enzymes. The temporal relationship suggests the vaccine as a potential inciting factor.