Journal
BMC RESEARCH NOTES
Volume 14, Issue 1, Pages -Publisher
SPRINGERNATURE
DOI: 10.1186/s13104-021-05704-7
Keywords
Extracellular histones; ARDS; Sepsis; Porcine; Lung damage; Experimental
Categories
Funding
- Projekt DEAL
Ask authors/readers for more resources
The study confirmed the proinflammatory effects of extracellular histones in a prospective translational porcine model, without significant differences in tissue damage between the groups.
Objective Extracellular histones have been identified as one molecular factor that can cause and sustain alveolar damage and were linked to high mortality rates in critically ill patients. In this pilot study, we wanted to validate the proinflammatory in vivo effects of local histone application in a prospective translational porcine model. This was combined with the evaluation of an experimental acute lung injury model using intrabronchial lipopolysaccharides, which has been published previously. Results The targeted application of histones was successful in all animals. Animals showed decreased oxygenation after instillation, but no differences could be detected between the sham and histone treatments. The histologic analyses and inflammatory responses indicated that there were no differences in tissue damage between the groups.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available