Journal
HORMONE RESEARCH IN PAEDIATRICS
Volume 86, Issue 1, Pages 3-10Publisher
KARGER
DOI: 10.1159/000444677
Keywords
Childhood obesity; MicroRNA; Biogenesis
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Obesity is a major health concern. While some children develop comorbidities such as insulin resistance and low-grade systemic inflammation upon weight gain, others stay metabolically healthy. There is an urgent need for clinically relevant markers with prognostic value related to disease development and intervention success. MicroRNAs (miRNAs) are established biomarkers for several disease states. Herein, we give a brief overview of miRNA biogenesis and function and the potential role of circulating miRNA in the context of pediatric obesity. (C) 2016 S. Karger AG, Basel
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