Coronavirus disease 2019 outcomes in heart transplant recipients: a single-center case series

Background With the rapidly expanding pandemic of severe acute respiratory syndrome coronavirus-2, a chronic immunosuppressed state in solid organ transplant recipients is a concern. We reported coronavirus disease 2019 in heart transplant recipients and described the patients' course from diagnosis to either hospital admission or improvement in symptoms. Case presentation This study retrospectively identified 13 white (Iranian) heart transplant patients with coronavirus disease 2019 between December 2019 and October 2020. The mean age of patients was 43.7 years (19-65 years); seven (70%) were men. Laboratory and treatment data were collected for those admitted or managed as outpatients. Outcomes were also recorded for all patients. This report demonstrates a range of symptoms, clinical severity, and disease course in heart transplant recipients with coronavirus disease 2019, including ten hospitalized patients and three patients, managed entirely in the outpatient setting. One patient passed away, and none of them experienced an episode of clinically overt rejection. Conclusions We would like to emphasize the importance of being alert in these patients to consider testing in a broad range of clinical presentations and gathering more data for better management.

Automated summary

This study investigated 13 heart transplant recipients with coronavirus disease 2019, highlighting the range of symptoms, clinical severity, and disease course in these patients, with some requiring hospitalization and others managing symptoms in the outpatient setting. Unfortunately, one patient passed away, but none experienced clinically overt rejection. The importance of vigilance and testing in various clinical presentations for better management in this patient population was emphasized.