Journal
HIPPOCAMPUS
Volume 26, Issue 6, Pages 763-778Publisher
WILEY
DOI: 10.1002/hipo.22557
Keywords
adult neurogenesis; dentate gyrus; hippocampus; granule cells; inhibition; optogenetics; interneurons
Categories
Funding
- New York State Stem Cell Initiative [NYSTEM C026430]
- NIH [R01 NS-081203]
- Kavli Foundation
- NIMH [K01 MH-099371]
- NYS Office of Mental Health
Ask authors/readers for more resources
Robust incorporation of new principal cells into preexisting circuitry in the adult mammalian brain is unique to the hippocampal dentate gyrus (DG). We asked if adult-born granule cells (GCs) might act to regulate processing within the DG by modulating the substantially more abundant mature GCs. Optogenetic stimulation of a cohort of young adult-born GCs (0 to 7 weeks post-mitosis) revealed that these cells activate local GABAergic interneurons to evoke strong inhibitory input to mature GCs. Natural manipulation of neurogenesis by aging-to decrease it-and housing in an enriched environment-to increase it-strongly affected the levels of inhibition. We also demonstrated that elevating activity in adult-born GCs in awake behaving animals reduced the overall number of mature GCs activated by exploration. These data suggest that inhibitory modulation of mature GCs may be an important function of adult-born hippocampal neurons. (C) 2015 Wiley Periodicals, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available