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Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
Brian J. Druker et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism
Alexandr P. Kornev et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Structural biology of protein tyrosine kinases
S. W. Cowan-Jacob
CELLULAR AND MOLECULAR LIFE SCIENCES (2006)
Mechanisms of resistance to small molecule kinase inhibition in the treatment of solid tumors
Brian P. Rubin et al.
LABORATORY INVESTIGATION (2006)
Epidermal growth factor receptor inhibitors in development for the treatment of non-small cell lung cancer
John V. Heymach et al.
CLINICAL CANCER RESEARCH (2006)
Rational design of inhibitors that bind to inactive kinase conformations
Y Liu et al.
NATURE CHEMICAL BIOLOGY (2006)
Sunitinib malate for the treatment of solid tumours: a review of current clinical data
Robert J. Motzer et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2006)
Targeting multidrug resistance in cancer
G Szakács et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
An efficient rapid system for profiling the cellular activities of molecular libraries
JS Melnick et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Allosteric inhibitors of Bcr-abl-dependent cell proliferation
FJ Adrián et al.
NATURE CHEMICAL BIOLOGY (2006)
Effects of HER2 overexpression on cell signaling networks governing proliferation and migration
Alejandro Wolf-Yadlin et al.
MOLECULAR SYSTEMS BIOLOGY (2006)
Emerging roles of pseudokinases
Jerome Boudeau et al.
TRENDS IN CELL BIOLOGY (2006)
Patterns of pulmonary complications associated with sirolimus
Prashant N. Chhajed et al.
RESPIRATION (2006)
Small molecule glucokinase activators as glucose lowering agents: A new paradigm for diabetes therapy
Kevin R. Guertin et al.
CURRENT MEDICINAL CHEMISTRY (2006)
Dynamics of signaling by PKA
SS Taylor et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2005)
Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer
T Takano et al.
JOURNAL OF CLINICAL ONCOLOGY (2005)
Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: A north central cancer treatment group study
E Galanis et al.
JOURNAL OF CLINICAL ONCOLOGY (2005)
Cutaneous side-effects of kinase inhibitors and blocking antibodies
C Robert et al.
LANCET ONCOLOGY (2005)
Kinomics: Characterizing the therapeutically validated kinase space
M Vieth et al.
DRUG DISCOVERY TODAY (2005)
Features of selective kinase inhibitors
ZA Knight et al.
CHEMISTRY & BIOLOGY (2005)
Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib
EL Kwak et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
ERBB receptors and cancer: The complexity of targeted inhibitors
NE Hynes et al.
NATURE REVIEWS CANCER (2005)
A gain-of-function mutation of JAK2 in myeloproliferative disorders
R Kralovics et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
W Pao et al.
PLOS MEDICINE (2005)
A cell-based immunocytochemical assay for monitoring kinase signaling pathways and drug efficacy
HX Chen et al.
ANALYTICAL BIOCHEMISTRY (2005)
EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
S Kobayashi et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
E Weisberg et al.
CANCER CELL (2005)
Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors
CW Lindsley et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors
SF Barnett et al.
BIOCHEMICAL JOURNAL (2005)
Protein posttranslational modifications: The chemistry of proteome diversifications
CT Walsh et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)
Kinomics-structural biology and chemogenomics of kinase inhibitors and targets
M Vieth et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2004)
A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): Relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells
ER Wood et al.
CANCER RESEARCH (2004)
Prediction of resistance to small molecule FLT3 inhibitors: Implications for molecularly targeted therapy of acute leukemia
J Cools et al.
CANCER RESEARCH (2004)
Regulation of protein kinases: Controlling activity through activation segment conformation
B Nolen et al.
MOLECULAR CELL (2004)
Opinion - Switching on kinases: oncogenic activation of BRAF and the PDGFR family
NJ Dibb et al.
NATURE REVIEWS CANCER (2004)
Creating chemical diversity to target protein kinases
B Li et al.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2004)
Discovery of N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays
LJ Lombardo et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition
JF Ohren et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)
Strategies to overcome resistance to targeted protein kinase inhibitors
H Daub et al.
NATURE REVIEWS DRUG DISCOVERY (2004)
The role of erlotinib (Tarceva, OSI 774) in the treatment of non-small cell lung cancer
R Perez-Soler
CLINICAL CANCER RESEARCH (2004)
Identification of RET kinase inhibitors as potential new treatment for sporadic and inherited thyroid cancer
F Carlomagno et al.
JOURNAL OF CHEMOTHERAPY (2004)
Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase
SK Rabindran et al.
CANCER RESEARCH (2004)
Characterization of a conserved structural determinant controlling protein kinase sensitivity to selective inhibitors
S Blencke et al.
CHEMISTRY & BIOLOGY (2004)
Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor
MC Heinrich et al.
JOURNAL OF CLINICAL ONCOLOGY (2003)
A highly selective inhibitor of IκB kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice
KW McIntyre et al.
ARTHRITIS AND RHEUMATISM (2003)
Mutational analysis of the tyrosine kinome in colorectal cancers
A Bardelli et al.
SCIENCE (2003)
PKC412 overcomes resistance to imatinib in a murine model of FIP1L1-PDGFRα-induced myeloproliferative disease
J Cools et al.
CANCER CELL (2003)
Discovery of 5-[5-Fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase
L Sun et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models
FX Mahon et al.
BLOOD (2003)
Archaeal protein kinases and protein phosphatases: insights from genomics and biochemistry
PJ Kennelly
BIOCHEMICAL JOURNAL (2003)
Discovery and biological evaluation of potent dual ErbB-2/EGFR tyrosine kinase inhibitors: 6-thiazolylquinazolines
MD Gaul et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)
Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab
HS Cho et al.
NATURE (2003)
A putative molecular-activation switch in the transmembrane domain of erbB2
SJ Fleishman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
The protein kinase complement of the human genome
G Manning et al.
SCIENCE (2002)
Regulation of insulin receptor function by a small molecule insulin receptor activator
C Pender et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site
C Pargellis et al.
NATURE STRUCTURAL BIOLOGY (2002)
Protein kinases - the major drug targets of the twenty-first century?
P Cohen
NATURE REVIEWS DRUG DISCOVERY (2002)
Protein kinases as targets for anticancer agents: from inhibitors to useful drugs
D Fabbro et al.
PHARMACOLOGY & THERAPEUTICS (2002)
Design and discovery of small molecules targeting Raf-1 kinase
TB Lowinger et al.
CURRENT PHARMACEUTICAL DESIGN (2002)
Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
SM Graham et al.
BLOOD (2002)
Tyrosine kinase inhibitors: From rational design to clinical trials
P Traxler et al.
MEDICINAL RESEARCH REVIEWS (2001)
Small molecule insulin receptor activators potentiate insulin action in insulin-resistant cells
M Li et al.
DIABETES (2001)
The role of protein phosphorylation in human health and disease - Delivered on June 30th 2001 at the FEBS Meeting in Lisbon
P Cohen
EUROPEAN JOURNAL OF BIOCHEMISTRY (2001)
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
ME Gorre et al.
SCIENCE (2001)
Studies leading to the identification of ZD1839 (Iressa™):: An orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer
AJ Barker et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2001)
Specificity and mechanism of action of some commonly used protein kinase inhibitors
SP Davies et al.
BIOCHEMICAL JOURNAL (2000)