Journal
BRITISH JOURNAL OF PHARMACOLOGY
Volume 172, Issue 16, Pages 3945-3949Publisher
WILEY-BLACKWELL
DOI: 10.1111/bph.13182
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Funding
- Investissements d'Avenir
- INSERM
- ERA-Net for Research Programmes on Rare Diseases [E-Rare-013]
- Italian Association for Cancer Research
- European Commission
- Italian Ministry of Education, Universities and Research
- Italian Ministry of Health
- Division of Intramural Research of the National Institute of Allergy and Infectious Diseases
- Medical Research Council [G0802838]
- Wellcome Trust
- Helmut Horten Foundation
- Swiss National Science Foundation
- Chief Scientist Office [ETM/67, ETM/276, ETM/115, CZB/4/697] Funding Source: researchfish
- Medical Research Council [G0901113, G0802838, MR/M019764/1] Funding Source: researchfish
- Wellcome Trust [099251/Z/12/Z] Funding Source: researchfish
- MRC [G0802838, G0901113, MR/M019764/1] Funding Source: UKRI
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Chemokines and their receptors are essential regulators of in vivo leukocyte migration and, some years ago, a systematic nomenclature system was developed for the chemokine receptor family. Chemokine receptor biology and biochemistry was recently extensively reviewed. In this review, we also highlighted a new component to the nomenclature system that incorporates receptors previously known as scavenging', or decoy', chemokine receptors on the basis of their lack of classical signalling responses to ligand binding and their general ability to scavenge, or sequester, their cognate chemokine ligands. These molecules are now collectively referred to as atypical chemokine receptors', or ACKRs, and play fundamental roles in regulating in vivo responses to chemokines. This commentary highlights this new addition to the chemokine receptor nomenclature system and provides brief information on the four receptors currently covered by this nomenclature.
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